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Role of Dopamine for Symptom Management in Palliative Care? Antipsychotics for Off-Label Uses

Antipsychotics are widely used off-label in clinical practice, especially within palliative care. Palliative care and hospice clinicians often prescribe antipsychotics for off-label uses such as delirium, nausea, agitation, and insomnia even though controversial evidence exist for their use for these indications, given antipsychotics' daunting side effect profile. A review of literature of antipsychotics for off-label uses will be completed and supplemented by expert opinion in a debate format as there are known risks and benefits to antipsychotic use, even when used more liberally in the palliative care world.

This activity aims to review pharmacotherapy principles of antipsychotics, to help tailor antipsychotic selection, and provide evidence-based published examples for the off-label use of antipsychotics in palliative care clinical practice.


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The American Academy of Hospice and Palliative Medicine (AAHPM) is the professional organization for physicians, nurses and other health care providers specializing in hospice and palliative care. Learn more.

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