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Does local conservative treatment for cervical intraepithelial neoplasia and early invasive cervical cancer adversely affect successful conception and early pregnancy outcomes in the first and second trimester (<24 weeks of gestation)?
Local cervical treatment does not adversely affect fertility or first trimester miscarriage, although it is associated with a significant increase in the risk of second trimester miscarriages.
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Corresponding Author: Maria Kyrgiou, MSc, PhD, MRCOG, Third Floor, Institute of Reproductive and Developmental Biology, Surgery and Cancer, Imperial College, Hammersmith Campus, Du Cane Road, W12 0NN, London, England (email@example.com).
Published Online: June 23, 2016. doi:10.1001/jamaoncol.2016.1839
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by a BSCCP Jordan/Singer Award (No. P47773); the Imperial College Healthcare Charity (No. P47907); the Imperial Healthcare National Health Service Trust National Institute for Health Research Biomedical Research Centre (No. P45272); and the Genesis Research Trust (No. P55549).
Role of the Funder/Sponsor: The funders/sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We acknowledge Marc Arbyn, MD (Scientific Institute for Public Health, Brussels, Belgium); Maria Paraskeviaidi, BSc (Imperial College London, England); Antonis Athanasiou (University Hospital of Ioannina, Greece); Pierre Martin-Hirsch, MBChB, MRCOG, MD (Lancaster University, City of Lancaster, England); and Philip Bennett, BSc, MBBS, MD, PhD, FRCOG (Imperial College London, London, England), for work on the original Cochrane review; as well as Clare Jess (Cochrane Collaboration) for editorial support. Ms Jess did not receive compensation for her contributions.
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