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Decreases in the cost of DNA sequencing have enabled substantial progress in fields ranging from archaeology and evolution to basic biomedical science. Concomitantly, there have been calls for routine genome-scale sequencing of healthy individuals in hopes of discovering clinically important information. For example, discovery of a high risk of breast and ovarian cancer due to a BRCA1/2 mutation can enable aggressive surveillance or risk-reducing surgery.
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Corresponding Author: James P. Evans, MD, PhD, Departments of Genetics and Medicine, CB #7264, Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264 (firstname.lastname@example.org).
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Berg reports being a funded investigator on the National Human Genome Research Institute–funded GeneScreen project, which is investigating the potential use of genomic screening of a small panel of genes in generally healthy adults. No other disclosures were reported.
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