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Familial hypercholesterolemia (FH) is a dominantly inherited genetic disorder affecting approximately 1 in 250 individuals. It is characterized by markedly elevated low-density lipoprotein cholesterol (LDL-C) and accelerated atherosclerotic cardiovascular disease (ASCVD).1 Persons with FH have a 2.5- to 10-fold increased risk of ASCVD compared with controls, but when FH is diagnosed and treated early in life, the risk is greatly reduced (≈ 80%).1 However, most people with FH have never been diagnosed or treated. Active case finding of FH plus family-based cascade screening can help identify individuals with FH and ensure treatment before ASCVD onset.
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Corresponding Author: Joshua W. Knowles, MD, PhD, Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University Falk Cardiovascular Research Center, 870 Quarry Rd, Stanford, CA 94304 (email@example.com).
Correction: This article was corrected online August 4, 2017, to insert a thematic label.
Conflict of Interest Disclosures: The author has completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Knowles reports grants paid to the institution from the American Heart Association and Amgen. No other disclosures were reported.
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