Metastatic neuroblastoma
C. Admit for urgent imaging and inpatient workup
Acute-onset proptosis in a child is always concerning, and urgent imaging should be obtained. Several underlying etiologies are possible, including an orbital infection or a neoplastic process (neuroblastoma, rhabdomyosarcoma, leukemia, and Langerhans cell histiocytosis). Because these processes can rapidly become vision- or life-threatening, urgent imaging is warranted, and observation, further workup as an outpatient, and broadening antibiotic coverage are not appropriate. Other orbital processes that lead to subacute or chronic proptosis in children include capillary hemangioma, optic nerve glioma, venolymphatic malformation, dermoid cyst, orbital pseudotumor or other inflammatory process, and thyroid eye disease.1,2