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Bilateral Blurry Vision in a Human Leukocyte Antigen B27–Positive Man

Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.
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Article Information

Corresponding Author: Jennifer I. Lim, MD, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855 W Taylor St, Chicago, IL 60612 (jennylim@uic.edu).

Published Online: February 28, 2019. doi:10.1001/jamaophthalmol.2018.6794

Conflict of Interest Disclosures: Dr Lim reports receiving grant support from Janssen, Alimera, and Second Sight; personal fees from pSivida, Alcon, Janssen, Santen, and Kodiak; and grants and personal fees from Genentech. No other disclosures were reported.

Funding/Support: Funding was provided through the National Institutes of Health grant P30 EY001792 and unrestricted departmental funding from Research to Prevent Blindness.

Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Disclaimer: Dr Lim is an Associate Deputy Editor of JAMA Ophthalmology, but she was not involved in any of the decisions regarding review of the manuscript or its acceptance.

Additional Contributions: We thank the patient for granting permission to publish this information.

References
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Braakenburg  AM, Rothova  A.  The clinical characteristics of retinal vasculitis in HLA-B27-positive patients.  Ocul Immunol Inflamm. 2014;22(3):197-202. doi:10.3109/09273948.2013.835429PubMedGoogle ScholarCrossref
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Holland  GN; Executive Committee of the American Uveitis Society.  Standard diagnostic criteria for the acute retinal necrosis syndrome.  Am J Ophthalmol. 1994;117(5):663-667. doi:10.1016/S0002-9394(14)70075-3PubMedGoogle ScholarCrossref
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Oliver  SE, Aubin  M, Atwell  L,  et al.  Ocular syphilis—eight jurisdictions, United States, 2014-2015.  MMWR Morb Mortal Wkly Rep. 2016;65(43):1185-1188. doi:10.15585/mmwr.mm6543a2PubMedGoogle ScholarCrossref
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Eandi  CM, Neri  P, Adelman  RA, Yannuzzi  LA, Cunningham  ET  Jr; International Syphilis Study Group.  Acute syphilitic posterior placoid chorioretinitis: report of a case series and comprehensive review of the literature.  Retina. 2012;32(9):1915-1941. doi:10.1097/IAE.0b013e31825f3851PubMedGoogle ScholarCrossref
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Pichi  F, Ciardella  AP, Cunningham  ET  Jr,  et al.  Spectral domain optical coherence tomography findings in patients with acute syphilitic posterior placoid chorioretinopathy.  Retina. 2014;34(2):373-384. doi:10.1097/IAE.0b013e3182993f11PubMedGoogle ScholarCrossref
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