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Hormone therapy is the most effective treatment for managing menopausal vasomotor symptoms. Hot flashes and night sweats affect approximately 70% of midlife women and may persist for a decade or longer.1 Bothersome vasomotor symptoms have a significant adverse effect on sleep, daily functioning, and quality of life. Cognitive and mood symptoms often accompany disruptive hot flashes. Although lifestyle changes and nonhormonal options are available, women with frequent, severe vasomotor symptoms may greatly benefit from hormone therapy.2
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Corresponding Author: Jan L. Shifren, MD, Midlife Women’s Health Center, Department of Obstetrics and Gynecology, Massachusetts General Hospital, 55 Fruit St, Yawkey 10A, Boston, MA 02114 (firstname.lastname@example.org).
Published Online: May 30, 2019. doi:10.1001/jama.2019.5346
Conflict of Interest Disclosures: Dr Shifren reported receiving personal fees from the New England Research Institute for research consulting. Dr Manson reported receiving grants from the National Institutes of Health.
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