Accepted for Publication: May 28, 2019.
Published: July 17, 2019. doi:10.1001/jamanetworkopen.2019.7216
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2019 Segura LE et al. JAMA Network Open.
Corresponding Author: Silvia S. Martins, MD, PhD, Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, Room 509, New York, NY 10032 (ssm2183@columbia.edu).
Author Contributions: Dr Segura had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Segura, Philbin, Martins.
Acquisition, analysis, or interpretation of data: Segura, C. M. Mauro, Levy, Khauli, P. M. Mauro, Martins.
Drafting of the manuscript: Segura, Levy, Khauli.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Segura, C. M. Mauro, Levy.
Obtained funding: Martins.
Administrative, technical, or material support: Segura, Khauli, Philbin, Martins.
Supervision: Segura, Philbin, Martins.
Conflict of Interest Disclosures: Dr C. M. Mauro reported grants from the National Institute on Drug Abuse during the conduct of the study. Dr Martins reported grants from the National Institute on Drug Abuse, National Institutes of Health during the conduct of the study. No other disclosures were reported.
Funding/Support: Funding for this project was provided by grant K01DA039804A (Dr Philbin), grant K01DA045224 (Dr P. M. Mauro), and grant R01DA037866 (Dr Martins) from the National Institute on Drug Abuse, National Institutes of Health.
Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The views expressed in this article are those of the authors and do not necessarily reflect those of the National Institute on Drug Abuse, National Institutes of Health.
2.Center for Behavioral Health Statistics and Quality. Results From the 2011 National Survey on Drug Use and Health: Summary of National Findings. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2012.
3.Substance Abuse and Mental Health Administration. 2015 National Survey on Drug Use and Health: Detailed Tables. Rockville, MD: Center for Behavioral Health Statistics and Quality; 2016.
10.Martins
SS, Sarvet
A, Santaella-Tenorio
J, Saha
T, Grant
BF, Hasin
DS. Changes in US lifetime heroin use and heroin use disorder: prevalence from the 2001-2002 to 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions.
JAMA Psychiatry. 2017;74(5):445-455. doi:
10.1001/jamapsychiatry.2017.0113PubMedGoogle ScholarCrossref 13.Centers for Disease Control and Prevention. Prescription drug overdoses—a U.S. epidemic.
MMWR Morb Mortal Wkly Rep. 2012;61(1):10-13.
PubMedGoogle Scholar 14.Centers for Disease Control and Prevention. Vital Signs: overdoses of prescription opioid pain relievers—United States, 1999-2008.
MMWR Morb Mortal Wkly Rep. 2011;60(43):1487-1492.
PubMedGoogle Scholar 20.Bachhuber
MA, Saloner
B, Cunningham
CO, Feingold
J, Barry
CL. Could Delaware’s medical marijuana law reduce harms from opioid analgesics?
Del Med J. 2014;86(11):341-343.
PubMedGoogle Scholar 25.Center for Behavioral Health Statistics and Quality. Behavioral Health Trends in the United States: Results From the 2014 National Survey on Drug Use and Health. Rockville, MD: Center for Behavioral Health Statistics and Quality; 2015.
27.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed, text revision. Washington, DC: American Psychiatric Association; 2000.
29.Lohr
SL. Sampling: Design and Analysis. Boston, MA: Cengage Learning; 2009.
36.Center for Behavioral Health Statistics and Quality. 2014 National Survey on Drug Use and Health: Methodological Summary and Definitions. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2015.