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2019 Novel Coronavirus—Important Information for Clinicians

Educational Objective
Review the evaluation criteria and current response to the 2019 Novel Coronavirus
1 Credit CME

In early December 2019 a patient was diagnosed with an unusual pneumonia in the city of Wuhan, China. By December 31 the World Health Organization (WHO) regional office in Beijing had received notification of a cluster of patients with pneumonia of unknown cause from the same city.1 Wuhan, the capital city of Hubei Province in central China, is the nation’s seventh largest city, with a population of 11 million people. Over the next few days, researchers at the Wuhan Institute of Virology performed metagenomics analysis using next-generation sequencing from a sample collected from a bronchoalveolar lavage and identified a novel coronavirus as the potential etiology. They called it novel coronavirus 2019 (nCoV-2019).2 The US Centers for Disease Control and Prevention (CDC) refers to it as 2019 novel coronavirus (2019-nCoV).3

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Article Information

Corresponding Author: Carlos del Rio, MD, Emory University School of Medicine, 69 Jesse Hill Jr Dr, FOB Room 201, Atlanta, GA 30303 (cdelrio@emory.edu).

Published Online: February 5, 2020. doi:10.1001/jama.2020.1490

Conflict of Interest Disclosures: Dr Del Rio reports receiving grants from the National Institute of Allergy and Infectious Diseases, National Institutes of Health. Dr Malani reported no disclosures.

References
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Paules  CI, Marston  HD, Fauci  AS.  Coronavirus infections—more than just the common cold.  JAMA. Published online January 23, 2020. doi:10.1001/jama.2020.0757PubMedGoogle Scholar
2.
Zhou  P, Yang  XL, Wang  XG,  et al. Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin. Preprint. https://www.biorxiv.org/content/10.1101/2020.01.22.914952v2.full.pdf. Posted January 23, 2020. Accessed February 3, 2020.
3.
Centers for Disease Control and Prevention. Coronavirus. https://www.cdc.gov/coronavirus/about/index.html. Accessed February 2, 2020.
4.
Wu  JT, Leung  K, Leung  GM.  Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study.  Lancet. Published online January 31, 2020. doi:10.1016/S0140-6736(20)30260-9Google Scholar
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Cohen  J.  Mining coronavirus genomes for clues to the outbreak’s origins.  Science. Published online January 31, 2020. doi:10.1126/science.abb1256Google Scholar
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Li  Q, Guan  X, Wu  P,  et al.  Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia.  N Engl J Med. Published online January 29, 2020. doi:10.1056/NEJMoa2001316PubMedGoogle Scholar
7.
Chen  N, Zhou  M, Dong  X,  et al.  Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.  Lancet. Published online January 30, 2020. doi:10.1016/S0140-6736(20)30211-7PubMedGoogle Scholar
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Huang  C,  et al.  Clinical feature of patients infected with 2019 novel coronavirus in Wuhan, China.  Lancet. Published online January 24, 2020. doi:10.1016/S0140-6736(20)30183-5Google Scholar
9.
Holshue  ML, DeBolt  C, Lindquist  S,  et al; Washington State 2019-nCoV Case Investigation Team.  First case of 2019 novel coronavirus in the United States.  N Engl J Med. Published online January 31, 2020. doi:10.1056/NEJMoa2001191PubMedGoogle Scholar
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Phelan  AL, Katz  R, Gostin  LO.  The novel coronavirus originating in Wuhan, China: challenges for global health governance.  JAMA. Published online January 30, 2020. doi:10.1001/jama.2020.1097Google Scholar
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