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Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China

Educational Objective
Review the demographic, epidemiologic, and clinical features of the children infected with COVID-19 in China
1 Credit CME

Since December 8, 2019, an epidemic of coronavirus disease 2019 (COVID-19) has spread rapidly.1 As of February 6, 2020, China reported 31 211 confirmed cases of COVID-19 and 637 fatalities.

Previous studies suggest that COVID-19 is more likely to infect older adult men, particularly those with chronic comorbidities.24 Few infections in children have been reported. We identified all infected infants in China and described demographic, epidemiologic, and clinical features.

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Article Information

Corresponding Author: Zhi-Jiang Zhang, MD, PhD, Department of Preventive Medicine, School of Health Sciences, Wuhan University, No. 185 Donghu Rd, Wuhan 430071, China (zhang22968@163.com).

Published Online: February 14, 2020. doi:10.1001/jama.2020.2131

Author Contributions: Dr Zhang had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Wei, Yuan, and Liu contributed equally.
Concept and design: Zhang.
Acquisition, analysis, or interpretation of data: Wei, Yuan, Liu, Fu, Yu, Zhang.
Drafting of the manuscript: Wei, Zhang.
Critical revision of the manuscript for important intellectual content: Yuan, Liu, Fu, Yu, Zhang.
Statistical analysis: Liu, Yu, Zhang.
Obtained funding: Zhang.
Administrative, technical, or material support: Zhang.
Supervision: Zhang.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was funded by the National Natural Science Foundation of China (grant 81641123) and the Fundamental Research Funds for the Central Universities (grant 2042017kf0193).

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions: We thank all patients involved in the study.

References
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Paules  CI, Marston  HD, Fauci  AS.  Coronavirus infections—more than just the common cold  [published online January 23, 2020].  JAMA. doi:10.1001/jama.2020.0757PubMedGoogle Scholar
2.
Chen  N, Zhou  M, Dong  X,  et al.  Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study  [published online January 30, 2020].  Lancet. doi:10.1016/S0140-6736(20)30211-7PubMedGoogle Scholar
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Wang  D, Hu  B, Hu  C, Zhu  F, Liu  X, Zhang  J.  Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan  [published online February 7, 2020].  JAMA. doi:10.1001/jama.2020.1585PubMedGoogle Scholar
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Li  Q, Guan  X, Wu  P,  et al.  Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia  .  N Engl J Med [published online January 29, 2020]. doi:10.1056/NEJMoa2001316PubMedGoogle Scholar
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Del Rio  C, Malani  PN.  2019 Novel coronavirus-important information for clinicians  [published online February 5, 2020].  JAMA. doi:10.1001/jama.2020.1490PubMedGoogle Scholar
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