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Preparing for the Most Critically Ill Patients With COVID-19The Potential Role of Extracorporeal Membrane Oxygenation

Educational Objective
Understand the importance of extracoporeal membrance oxygenation (ECMO) for the most vulnerable patients in combating COVID-19
1 Credit CME

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Article Information

Corresponding Author: Graeme MacLaren, MSc, Cardiothoracic Intensive Care Unit, National University Health System, 5 Lower Kent Ridge Rd, Singapore 119074 (gmaclaren@iinet.net.au).

Published Online: February 19, 2020. doi:10.1001/jama.2020.2342

Conflict of Interest Disclosures: Dr Brodie reported receiving grants from Alung Technologies, serving on the medical advisory board for Alung Technologies, Xenios, Breethe, Baxter, and Hemovent. No other disclosures were reported.

References
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Paules  CI , Marston  HD , Fauci  AS .  Coronavirus infections—more than just the common cold.   JAMA. 2020. Published online January 23, 2020. doi:10.1001/jama.2020.0757PubMedGoogle Scholar
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World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected—interim guidance. Published January 28, 2020. Accessed February 11, 2020. https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected
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Wang  D , Hu  B , Hu  C ,  et al.  Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China.   JAMA. Published online February 7, 2020. doi:10.1001/jama.2020.1585Google Scholar
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Chen  N , Zhou  M , Dong  X ,  et al.  Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.   Lancet. Published online January 30, 2020. doi:10.1016/S0140-6736(20)30211-7Google Scholar
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Brodie  D , Slutsky  AS , Combes  A .  Extracorporeal life support for adults with respiratory failure and related indications: a review.   JAMA. 2019;322(6):557-568. doi:10.1001/jama.2019.9302PubMedGoogle ScholarCrossref
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Goligher  EC , Tomlinson  G , Hajage  D ,  et al.  Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc bayesian analysis of a randomized clinical trial.   JAMA. 2018;320(21):2251-2259. doi:10.1001/jama.2018.14276PubMedGoogle ScholarCrossref
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Barbaro  RP , Odetola  FO , Kidwell  KM ,  et al.  Association of hospital-level volume of extracorporeal membrane oxygenation cases and mortality. Analysis of the extracorporeal life support organization registry.   Am J Respir Crit Care Med. 2015;191(8):894-901. doi:10.1164/rccm.201409-1634OCPubMedGoogle ScholarCrossref
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White  DB , Angus  DC .  Preparing for the sickest patients with 2009 influenza A(H1N1).   JAMA. 2009;302(17):1905-1906. doi:10.1001/jama.2009.1539PubMedGoogle ScholarCrossref
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