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Presumed Asymptomatic Carrier Transmission of COVID-19

Educational Objective
Understand the transmission rates of asymptomatic carriers of COVID-19
1 Credit CME

A novel coronavirus has resulted in an ongoing outbreak of viral pneumonia in China.13 Person-to-person transmission has been demonstrated,1 but, to our knowledge, transmission of the novel coronavirus that causes coronavirus disease 2019 (COVID-19) from an asymptomatic carrier with normal chest computed tomography (CT) findings has not been reported.

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Article Information

Corresponding Author: Meiyun Wang, MD, PhD, Department of Medical Imaging, Henan Provincial People’s Hospital and the People’s Hospital of Zhengzhou University, No. 7, WeiWu Road, Zhengzhou 450003, Henan, China (mywang@ha.edu.cn).

Published Online: February 21, 2020. doi:10.1001/jama.2020.2565

Author Contributions: Drs Yao and Wang had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Bai, Yao, and Wei contributed equally to the work.

Concept and design: Bai, Yao, Tian, Jin, Wang.

Acquisition, analysis, or interpretation of data: Bai, Yao, Wei, Tian, Chen, Wang.

Drafting of the manuscript: Bai, Yao, Wei, Tian, Wang.

Critical revision of the manuscript for important intellectual content: Bai, Tian, Jin, Chen, Wang.

Statistical analysis: Bai, Chen, Wang.

Administrative, technical, or material support: Bai, Yao, Wei, Tian, Wang.

Supervision: Tian, Wang.

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank Taiyuan Liu, MD, Rushi Chen, MD, and Wei Wei, MD (Henan Provincial People’s Hospital and the People’s Hospital of Zhengzhou University), for data analysis and literature research. None of these persons received any compensation for their contributions.

References
1.
Paules  CI , Marston  HD , Fauci  AS .  Coronavirus infections—more than just the common cold.   JAMA. Published online January 23, 2020. doi:10.1001/jama.2020.0757PubMedGoogle Scholar
2.
Li  Q , Guan  X , Wu  P ,  et al.  Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia.   N Engl J Med. Published online January 29, 2020. doi:10.1056/NEJMoa2001316PubMedGoogle Scholar
3.
Wang  D , Hu  B , Hu  C ,  et al.  Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China.   JAMA. Published online February 7, 2020. doi:10.1001/jama.2020.1585PubMedGoogle Scholar
4.
Guan  WJ , Ni  ZY , Hu  Y ,  et al. Clinical characteristics of 2019 novel coronavirus infection in China. medRxiv. Published February 9, 2020. Accessed February 18, 2020. https://www.medrxiv.org/content/10.1101/2020.02.06.20020974v1
5.
Corman  VM , Landt  O , Kaiser  M ,  et al.  Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.   Euro Surveill. Published online January 23, 2020. doi:10.2807/1560-7917.ES.2020.25.3.2000045PubMedGoogle Scholar
6.
Chan  JF , Yuan  S , Kok  KH ,  et al.  A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.   Lancet. 2020;395(10223):514-523. doi:10.1016/S0140-6736(20)30154-9PubMedGoogle ScholarCrossref
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