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COVID-19—New Insights on a Rapidly Changing Epidemic

Educational Objective
Review the most up to date insights on COVID-19
1 Credit CME

Since first reported in Wuhan, China, in late December 2019, the outbreak of the novel coronavirus now known as SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has spread globally. As of February 27, 2020, more than 82 000 cases of coronavirus disease 2019 (COVID-19) (the disease caused by SARS-CoV-2) and 2800 deaths have been reported, of which approximately 95% of cases and 97% of deaths are in China.1 Cases have now been reported in 49 other countries. A particularly large outbreak occurred among the passengers and crew of the Diamond Princess cruise ship, where more than 700 infections are reported.

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Article Information

Corresponding Author: Carlos del Rio, MD, Emory University School of Medicine, 49 Jesse Hill Jr Dr, FOB Room 201, Atlanta, GA 30303 (cdelrio@emory.edu).

Published Online: February 28, 2020. doi:10.1001/jama.2020.3072

Correction: This article was corrected on March 6, 2020, to correct the paragraph under “Screening and Testing” that outlines the specimens recommended for PCR testing.

Conflict of Interest Disclosures: Dr Del Rio reports receiving grants from NIAID. Dr Malani reported no disclosures.

References
1.
Wu  Z , McGoogan  JM .  Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention.   JAMA. Published February 24, 2020. doi:10.1001/jama.2020.2648PubMedGoogle Scholar
2.
Del Rio  C , Malani  P .  Novel coronavirus—important information for clinicians.   JAMA. Published February 5, 2020. doi:10.1001/jama.2020.1490PubMedGoogle Scholar
3.
Bai  Y , Yao  L , Wei  T ,  et al.  Presumed asymptomatic carrier transmission of COVID-19.   JAMA. Published online February 21, 2020. doi:10.1001/jama.2020.2565PubMedGoogle Scholar
4.
Zhang  W , Du  RH , Li  B ,  et al.  Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.   Emerg Microbes Infect. 2020;9(1):386-389. PubMedGoogle ScholarCrossref
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Wang  D , Hu  B , Hu  C ,  et al.  Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China.   JAMA. Published online February 7, 2020. doi:10.1001/jama.2020.1585PubMedGoogle Scholar
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Chen  H , Guo  J , Wang  C ,  et al.  Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women.   Lancet. Published February 12, 2020. doi:10.1016/S0140-6736(20)30360-3Google Scholar
7.
Bhatia  S , Imai  N , Cuomo-Dannenburg  G ,  et al. Report 6: relative sensitivity of international surveillance. Accessed February 24, 2020. https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-College—COVID-19—Relative-Sensitivity-International-Cases.pdf
8.
Chang  D , Lin  M , Wei  L ,  et al.  Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China.   JAMA. Published online February 7, 2020. doi:10.1001/jama.2020.1623PubMedGoogle Scholar
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