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Coronaviruses have been implicated in nosocomial outbreaks1 with environmental contamination as a route of transmission.2 Similarly, nosocomial transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported.3 However, the mode of transmission and extent of environmental contamination are unknown.
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Accepted for Publication: February 27, 2020.
Corresponding Authors: Kalisvar Marimuthu, MBBS (firstname.lastname@example.org), and Ng Oon Tek, MBBS, MPH (email@example.com), National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore 308442.
Published Online: March 4, 2020. doi:10.1001/jama.2020.3227
Author Contributions: Drs Ong and Marimuthu had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Wong and Marimuthu contributed equally as senior authors.
Concept and design: Ong, Ng, Wong, Marimuthu.
Acquisition, analysis, or interpretation of data: Ong, Tan, Chia, Lee, Ng, Wong, Marimuthu.
Drafting of the manuscript: Ong, Ng, Wong, Marimuthu.
Critical revision of the manuscript for important intellectual content: Ong, Tan, Chia, Lee, Ng, Wong, Marimuthu.
Statistical analysis: Ong, Marimuthu.
Obtained funding: Wong, Marimuthu.
Administrative, technical, or material support: Ong, Tan, Chia, Ng, Wong, Marimuthu.
Supervision: Ng, Marimuthu.
Conflict of Interest Disclosures: None reported.
Funding/Support: Funding for this study was supported by the National Medical Research Council (NMRC) Seed Funding Program (TR19NMR119SD) and internal funds from DSO National Laboratories. Dr Ng is supported by NMRC Clinician Scientist Award MOH-000276. Dr Marimuthu is supported by an NMRC Clinician-Scientist Individual Research Grant (CIRG18Nov-0034).
Role of the Funder/Sponsor: The funding bodies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
Additional Contributions: We thank Barnaby Edward Young, MB, BChir, and Ding Ying, PhD, National Centre for Infectious Diseases, Singapore, for assistance with sample processing; Marcus Gum, BSc, and Yvonne Lau, PhD, DSO National Laboratories, Singapore, for assistance with sample RT-PCR testing; and Brenda Sze Peng Ang, MBBS, National Centre for Infectious Diseases, Boon Huan Tan, PhD, DSO National Laboratories, and Yee-Sin Leo, MBBS, National Centre for Infectious Diseases, for overall supervision and guidance. No compensation was received for their roles in the study.
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