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Coronavirus (COVID-19)

Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China

Educational Objective
To understand Neonatal Early-Onset infection with SARS-CoV-2
1 Credit CME
JAMA Pediatrics
Published Online: March 26, 2020
Research Letter
Lingkong Zeng, MD1;
Shiwen Xia, MD2;
Wenhao Yuan, MD1;
Kai Yan, MD3;
Feifan Xiao, MS3;
Jianbo Shao, MD4;
Wenhao Zhou, MD3
Author Affiliations
  • 1Department of Neonatology, Institute of Maternal and Child Health, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  • 2Department of Neonatology, Maternal and Child Health Hospital of Hubei Province, Wuhan, China
  • 3National Children's Medical Center, Children’s Hospital of Fudan University, Shanghai, China
  • 4Institute of Maternal and Child Health, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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The coronavirus disease 2019 (COVID-19) has spread rapidly across the world. With the sharp increase in the number of infections, the number of pregnant women and children with COVID-19 is also on the rise. However, only 19 neonates born to affected mothers have been investigated, and to our knowledge, no information on early-onset infection in newborns has been published in previous studies.1,2

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Global Health Neonatology Pediatrics Coronavirus (COVID-19)
Article Information

Accepted for Publication: March 10, 2020.

Corresponding Author: Wenhao Zhou, MD, National Children's Medical Center, Children’s Hospital of Fudan University, 399 Wanyuan Rd, Shanghai 201102, China (zhouwenhao@fudan.edu.cn).

Published Online: March 26, 2020. doi:10.1001/jamapediatrics.2020.0878

Author Contributions: Dr Zeng had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Zeng, Shao, Zhou.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: All authors.

Critical revision of the manuscript for important intellectual content: Xia, Yuan, Xiao, Shao, Zhou.

Statistical analysis: Zeng, Yuan, Yan, Xiao.

Administrative, technical, or material support: Zeng, Xia, Yan, Shao, Zhou.

Supervision: Shao, Zhou.

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank Shoo K. Lee, MD, Department of Obstetrics and Gynecology and Department of Public Health, University of Toronto, for editing assistance. He was compensated for his contribution. We thank the patients’ families for granting permission to publish this information.

References
1.
Zhu  H , Wang  L , Fang  C ,  et al.  Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia.   Transl Pediatr. 2020;9(1):51-60. doi:10.21037/tp.2020.02.06 PubMedGoogle ScholarCrossref
2.
Chen  H , Guo  J , Wang  C ,  et al.  Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.   Lancet. 2020;395(10226):809-815. doi:10.1016/S0140-6736(20)30360-3PubMedGoogle ScholarCrossref
3.
National Health Commission of China. New coronavirus pneumonia prevention and control program (4th edition). Accessed March 9, 2020. http://www.gov.cn/zhengce/zhengceku/2020-01/28/5472673/files/0f96c10cc09d4d36a6f9a9f0b42d972b.pdf.
4.
Wang  L , Shi  Y , Xiao  T ,  et al; Working Committee on Perinatal and Neonatal Management for the Prevention and Control of the 2019 Novel Coronavirus Infection.  Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (first edition).   Ann Transl Med. 2020;8(3):47. doi:10.21037/atm.2020.02.20PubMedGoogle ScholarCrossref
5.
Wei  M , Yuan  J , Liu  Y , Fu  T , Yu  X , Zhang  ZJ .  Novel coronavirus infection in hospitalized infants under 1 year of age in China.   JAMA. 2020. doi:10.1001/jama.2020.2131PubMedGoogle Scholar
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