[Skip to Content]
[Skip to Content Landing]

Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn

Educational Objective
To understand how COVID-19 can be transmitted from mother to infants during pregnancy and delivery
1 Credit CME

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly infectious, with multiple possible routes of transmission.13 Controversy exists regarding whether SARS-CoV-2 can be transmitted in utero from an infected mother to her infant before birth. A series of 9 pregnant women found no mother-child transmission.4 We report a newborn with elevated IgM antibodies to SARS-CoV-2 born to a mother with coronavirus disease 2019 (COVID-19).

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 CME Credit™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

Article Information

Corresponding Authors: Jing Yang, MD, Department of Obstetrics & Gynecology, Renmin Hospital of Wuhan University, 283 Jiefang Rd, Wuhan, Hubei 430060, China (13507182023@163.com); Chen Liu, MD, Department of Radiology, First Affiliated Hospital to Army Medical University, 30 Gao Tan Yan St, Chongqing 400038, China (liuchen@aifmri.com).

Published Online: March 26, 2020. doi:10.1001/jama.2020.4621

Author Contributions: Drs Liu and Yang had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Dong and Tian contributed equally to the study. Drs Liu and Yang contributed equally as senior authors.

Concept and design: Wang, Liu, Yang.

Acquisition, analysis, or interpretation of data: Dong, Tian, He, Zhu.

Drafting of the manuscript: Dong, Tian, He, Zhu, Liu.

Critical revision of the manuscript for important intellectual content: Zhu, Wang, Liu, Yang.

Statistical analysis: Dong, Tian, He, Liu.

Obtained funding: Zhu, Wang, Liu, Yang.

Supervision: Zhu, Yang.

Conflict of Interest Disclosures: None reported.

Funding/Support: This work was supported by the Chongqing Key technology and application demonstration of medical imaging depth intelligent diagnostic platform (cstc2018jszx-cyztzxX0017), the National Key Research and Development Project (2018YFC1002804, 2016YFC1000600), and the National Natural Science Foundation of China (No. 81771618 and No. 81801524).

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Additional Contributions: We thank the family members who were involved in this study and we thank the patient for granting permission to publish this information.

References
1.
Wang  W , Xu  Y , Gao  R ,  et al.  Detection of SARS-CoV-2 in different types of clinical specimens.   JAMA. Published March 11, 2020. doi:10.1001/jama.2020.3786Google Scholar
2.
Woo  PC , Lau  SK , Wong  BH ,  et al.  Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia.   J Clin Microbiol. 2004;42(5):2306-2309. doi:10.1128/JCM.42.5.2306-2309.2004PubMedGoogle ScholarCrossref
3.
Xu  W , Li  J , He  X ,  et al.  The diagnostic value of joint detection of serum IgM and IgG antibodies to 2019-nCoV in 2019-nCoV infection.   Chinese J Lab Med. 2020;43(00):E012-E012. doi:10.3760/cma.j.cn114452-20200223-00109Google Scholar
4.
Chen  H , Guo  J , Wang  C ,  et al.  Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.   Lancet. 2020;395(10226):809-815. doi:10.1016/S0140-6736(20)30360-3PubMedGoogle ScholarCrossref
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_LoginSubscribe_Purchase
Close
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_LoginSubscribe_Purchase
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
jn-learning_Modal_SaveSearch_NoAccess_Purchase
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close