Antibodies in Infants Born to Mothers With COVID-19 | Infectious Diseases | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Antibodies in Infants Born to Mothers With COVID-19 Pneumonia

Educational Objective
To understand immunity transmission for COVID-19 from mother to infant during pregnancy
1 Credit CME

Tests for IgG and IgM antibodies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became available in February 2020. On March 4, 2020, the seventh edition of the New Coronavirus Pneumonia Prevention and Control Protocol for the novel coronavirus disease 2019 (COVID-19) was released by the National Health Commission of the People’s Republic of China and added serological diagnostic criteria.1 A previous study of 9 pregnant women and their infants found no maternal-infant transmission of SARS-CoV-2 based on reverse transcriptase–polymerase chain reaction (RT-PCR).2 We applied these new criteria to 6 pregnant women with confirmed COVID-19 and their infants because serologic criteria would allow more detailed investigation of infection in newborns.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 CME Credit™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

Article Information

Corresponding Authors: Xinghua Long, MD, PhD (zhoulongxinghua@qq.com) and Wei Zhang, MD, PhD (zw6676@163.com), Zhongnan Hospital of Wuhan University, 169 Donghu Rd, Wuhan, China.

Published Online: March 26, 2020. doi:10.1001/jama.2020.4861

Author Contributions: Drs Long and Zhang had full access to all the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis. Dr Zeng and Ms Xu contributed equally to the study.

Concept and design: Zeng, Xu, Long.
Acquisition, analysis, or interpretation of data: Fan, Tang, Deng, Zhang.
Drafting of the manuscript: Zeng, Xu, Long.
Critical revision of the manuscript for important intellectual content: Fang, Tang, Deng, Zhang.
Statistical analysis: Zeng, Xu, Fan, Tang, Deng.
Obtained funding: Long.
Supervision: Zhang.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported by grants 81272372 from the National Natural Science Foundation of China and znpy2016033 from Zhongnan Hospital of Wuhan University Science, Technology, and Innovation Seed Fund.

Role of the Funder/Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
1.
China  NHC . New Coronavirus Pneumonia Prevention and Control Protocol. 7th ed. National Health Commission of the People’s Republic of China; 2020. Accessed March 5, 2020. http://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989/files/ce3e6945832a438eaae415350a8ce964 .pdf
2.
Chen  H , Guo  J , Wang  C ,  et al.  Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.   Lancet. 2020;395(10226):809-815. doi:10.1016/S0140-6736(20)30360-3PubMedGoogle ScholarCrossref
3.
World Health Organization. Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases: interim guidance 2020. Posted January 17, 2020. Accessed March 5, 2020. https://www.who.int/publications-detail/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases- 20200117
4.
Contribution to Wuhan with SARS-CoV-2 IgG/IgM Assays. News release. YHLO, March 1, 2020. Accessed March 5, 2020. http://www.szyhlo.com/en/news_detail.php?menuid=75&id=125&from=singlemessage&isappinstalled=0.
5.
Kohler  PF , Farr  RS .  Elevation of cord over maternal IgG immunoglobulin: evidence for an active placental IgG transport.   Nature. 1966;210(5040):1070-1071. doi:10.1038/2101070a0PubMedGoogle ScholarCrossref
6.
Ng  WF , Wong  SF , Lam  A ,  et al.  The placentas of patients with severe acute respiratory syndrome: a pathophysiological evaluation.   Pathology. 2006;38(3):210-218. doi:10.1080/00313020600696280PubMedGoogle ScholarCrossref
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_LoginSubscribe_Purchase
Close
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_LoginSubscribe_Purchase
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
jn-learning_Modal_SaveSearch_NoAccess_Purchase
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close