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Clinical Characteristics of Patients Who Died of Coronavirus Disease 2019 in China

Educational Objective
To understand the clinical characteristics of those who died of COVID-19 in China
1 Credit CME

The outbreak of coronavirus disease 2019 (COVID-19) has been very severe in China.1 As of March 2020, many tens of thousands of patients have had confirmed COVID-19, and cases have been increasing daily.2 The mortality is much higher in Wuhan, China, than in other cities.3 To understand the characteristics of patients who die of COVID-19, we analyzed 168 patients with COVID-19–induced pneumonia who died.

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Article Information

Accepted for Publication: March 12, 2020.

Published: April 10, 2020. doi:10.1001/jamanetworkopen.2020.5619

Correction: This article was corrected on May 8, 2020, to fix an error in the third paragraph of the Discussion section.

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Xie J et al. JAMA Network Open.

Corresponding Author: Haibo Qiu, MD, PhD, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, No. 87, Dingjiaqiao Rd, Nanjing 210009, Jiangsu, China (haiboq2000@163.com).

Author Contributions: Drs Xie and Qiu had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Xie, Guan, Du, Qiu.

Acquisition, analysis, or interpretation of data: Xie, Tong, Du, Qiu.

Drafting of the manuscript: Xie, Qiu.

Critical revision of the manuscript for important intellectual content: Tong, Guan, Du, Qiu.

Statistical analysis: Xie, Tong, Qiu.

Obtained funding: Du, Qiu.

Administrative, technical, or material support: Tong.

Supervision: Tong, Guan, Du, Qiu

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was supported by grants 2020YFC0841300 and 2020YFC0843700 from the Ministry of Science and Technology of the People’s Republic of China.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
1.
Wang  D , Hu  B , Hu  C ,  et al.  Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China.   JAMA. Published online February 7, 2020. doi:10.1001/jama.2020.1585PubMedGoogle Scholar
2.
National Health Commission of the People’s Republic of China. Bulletin of the National Health Commission of the People’s Republic of China on the 2019 new coronavirus infection. Accessed March 8, 2020. http://www.nhc.gov.cn/xcs/xxgzbd/gzbd_index.shtml
3.
World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. Accessed March 8, 2020. https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected
4.
Ferrer  M , Torres  A .  Noninvasive ventilation for acute respiratory failure.   Curr Opin Crit Care. 2015;21(1):1-6. doi:10.1097/MCC.0000000000000173PubMedGoogle ScholarCrossref
5.
Xie  J , Wang  H , Kang  Y ,  et al; Chinese Epidemiological Study of Sepsis (CHESS) Study Investigators.  The epidemiology of sepsis in Chinese ICUs: a national cross-sectional survey.   Crit Care Med. 2020;48(3):e209-e218. doi:10.1097/CCM.0000000000004155PubMedGoogle ScholarCrossref
6.
Zhao  Y , Zhao  Z , Wang  Y , Zhou  Y , Ma  Y , Zuo  W. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov. Preprint. Posted online January 26, 2020. bioRxiv 2020.01.26.919985. doi:10.1101/2020.01.26.919985
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