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Sudden and Complete Olfactory Loss Function as a Possible Symptom of COVID-19

Educational Objective
To understand possible symptom of COVID-19
1 Credit CME

The novel coronavirus disease 2019 (COVD-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects the human respiratory epithelial cells. The clinical features of patients infected with SARS-CoV-2 included lower respiratory tract infection with fever, dry cough, and dyspnea.1 In contrast, upper respiratory tract symptoms are less common, suggesting that the cells targeted by the virus could be located in the lower respiratory tract.1

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Article Information

Corresponding Author: Michael Eliezer, MD, Neuroradiology Unit, Lariboisière University Hospital, 75010 Paris, France (michael.eliezer@aphp.fr).

Published Online: April 8, 2020. doi:10.1001/jamaoto.2020.0832

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References
1.
Huang  C , Wang  Y , Li  X ,  et al.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.   Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5PubMedGoogle ScholarCrossref
2.
Seiden  AM , Duncan  HJ .  The diagnosis of a conductive olfactory loss.   Laryngoscope. 2001;111(1):9-14. doi:10.1097/00005537-200101000-00002PubMedGoogle ScholarCrossref
3.
Trotier  D , Bensimon  JL , Herman  P , Tran Ba Huy  P , Døving  KB , Eloit  C .  Inflammatory obstruction of the olfactory clefts and olfactory loss in humans: a new syndrome?   Chem Senses. 2007;32(3):285-292. doi:10.1093/chemse/bjl057PubMedGoogle ScholarCrossref
4.
Li  YC , Bai  WZ , Hashikawa  T .  The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients [published online February 27, 2020].   J Med Virol. doi:10.1002/jmv.25728PubMedGoogle Scholar
5.
Yao  L , Yi  X , Pinto  JM ,  et al.  Olfactory cortex and olfactory bulb volume alterations in patients with post-infectious olfactory loss.   Brain Imaging Behav. 2018;12(5):1355-1362. doi:10.1007/s11682-017-9807-7PubMedGoogle ScholarCrossref
6.
An  SS , Liggett  SB .  Taste and smell GPCRs in the lung: evidence for a previously unrecognized widespread chemosensory system.   Cell Signal. 2018;41:82-88. doi:10.1016/j.cellsig.2017.02.002PubMedGoogle ScholarCrossref
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