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Head and Neck Surgery

Sudden and Complete Olfactory Loss of Function as a Possible Symptom of COVID-19

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To understand possible symptom of COVID-19

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JAMA Otolaryngology–Head & Neck Surgery

July 1, 2020

Observation

Article Information and Disclosures

Michael Eliezer, MD¹;

Charlotte Hautefort, MD²;

Anne-Laure Hamel, MD²;

et al

Benjamin Verillaud, MD²;

Philippe Herman, MD, PhD²;

Emmanuel Houdart, MD, PhD¹;

Corinne Eloit, MD²

Author Affiliations

¹Department of Neuroradiology, Lariboisière University Hospital, Paris, France
²Department of Head and Neck Surgery, Lariboisière University Hospital, Paris, France

Read article on JAMA Network

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Olfactory Loss of Function as a Possible Symptom of COVID-19

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Matt Lechner, MD; Zara M. Patel, MD; Carl Philpott, MD; Valerie J. Lund, MD
Comment & Response

Olfactory Loss of Function as a Possible Symptom of COVID-19

Si Wei Kheok, MBBS; Neville W. Y. Teo, MBBS, MRCS, MMed

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The novel coronavirus disease 2019 (COVD-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects the human respiratory epithelial cells. The clinical features of patients infected with SARS-CoV-2 included lower respiratory tract infection with fever, dry cough, and dyspnea.¹ In contrast, upper respiratory tract symptoms are less common, suggesting that the cells targeted by the virus could be located in the lower respiratory tract.¹

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Article Information

Corresponding Author: Michael Eliezer, MD, Neuroradiology Unit, Lariboisière University Hospital, 75010 Paris, France (michael.eliezer@aphp.fr).

Published Online: April 8, 2020. doi:10.1001/jamaoto.2020.0832

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References

Huang C , Wang Y , Li X , et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5 PubMed Google Scholar Crossref

Seiden AM , Duncan HJ . The diagnosis of a conductive olfactory loss. Laryngoscope. 2001;111(1):9-14. doi:10.1097/00005537-200101000-00002 PubMed Google Scholar Crossref

Trotier D , Bensimon JL , Herman P , Tran Ba Huy P , Døving KB , Eloit C . Inflammatory obstruction of the olfactory clefts and olfactory loss in humans: a new syndrome? Chem Senses. 2007;32(3):285-292. doi:10.1093/chemse/bjl057 PubMed Google Scholar Crossref

Li YC , Bai WZ , Hashikawa T . The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients [published online February 27, 2020]. J Med Virol. doi:10.1002/jmv.25728 PubMed Google Scholar

Yao L , Yi X , Pinto JM , et al. Olfactory cortex and olfactory bulb volume alterations in patients with post-infectious olfactory loss. Brain Imaging Behav. 2018;12(5):1355-1362. doi:10.1007/s11682-017-9807-7 PubMed Google Scholar Crossref

An SS , Liggett SB . Taste and smell GPCRs in the lung: evidence for a previously unrecognized widespread chemosensory system. Cell Signal. 2018;41:82-88. doi:10.1016/j.cellsig.2017.02.002 PubMed Google Scholar Crossref

Sudden and Complete Olfactory Loss of Function as a Possible Symptom of COVID-19

Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection

Diagnosis and Management of Olfactory Dysfunction in COVID-19

Olfactory Loss of Function as a Possible Symptom of COVID-19

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Olfactory Loss of Function as a Possible Symptom of COVID-19

Persistent Symptoms in Patients After Acute COVID-19

Magnetic Resonance Imaging Alteration of the Brain in a Patient With COVID-19 and Anosmia

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