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Sudden and Complete Olfactory Loss of Function as a Possible Symptom of COVID-19

Educational Objective
To understand possible symptom of COVID-19
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Article Information

Corresponding Author: Michael Eliezer, MD, Neuroradiology Unit, Lariboisière University Hospital, 75010 Paris, France (michael.eliezer@aphp.fr).

Published Online: April 8, 2020. doi:10.1001/jamaoto.2020.0832

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References
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Huang  C , Wang  Y , Li  X ,  et al.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.   Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5PubMedGoogle ScholarCrossref
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Seiden  AM , Duncan  HJ .  The diagnosis of a conductive olfactory loss.   Laryngoscope. 2001;111(1):9-14. doi:10.1097/00005537-200101000-00002PubMedGoogle ScholarCrossref
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Trotier  D , Bensimon  JL , Herman  P , Tran Ba Huy  P , Døving  KB , Eloit  C .  Inflammatory obstruction of the olfactory clefts and olfactory loss in humans: a new syndrome?   Chem Senses. 2007;32(3):285-292. doi:10.1093/chemse/bjl057PubMedGoogle ScholarCrossref
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Li  YC , Bai  WZ , Hashikawa  T .  The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients [published online February 27, 2020].   J Med Virol. doi:10.1002/jmv.25728PubMedGoogle Scholar
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Yao  L , Yi  X , Pinto  JM ,  et al.  Olfactory cortex and olfactory bulb volume alterations in patients with post-infectious olfactory loss.   Brain Imaging Behav. 2018;12(5):1355-1362. doi:10.1007/s11682-017-9807-7PubMedGoogle ScholarCrossref
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An  SS , Liggett  SB .  Taste and smell GPCRs in the lung: evidence for a previously unrecognized widespread chemosensory system.   Cell Signal. 2018;41:82-88. doi:10.1016/j.cellsig.2017.02.002PubMedGoogle ScholarCrossref
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