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The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic InfectionNeurologists Move to the Frontlines

Educational Objective
To understand the types of neurological complications that can arise in patients with moderate to severe COVID-19 exposure
1 Credit CME

The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emerged as an unprecedented worldwide crisis in the early months of 2020, overwhelming health systems and challenging societies as we seek to contain its spread. In the tremendous flood of viral pneumonia cases and resultant life-threatening respiratory complications, the extent of potential neurologic manifestations of coronavirus disease 2019 (COVID-19) has remained unclear. In this issue of JAMA Neurology, a retrospective consecutive case series1 of 214 patients from Wuhan, China, with either moderate or severe COVID-19 reports an early view of the incidence and types of neurologic complications and sets the stage for future longitudinal work in the area.

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Article Information

Corresponding Author: S. Andrew Josephson, MD, University of California, San Francisco, Neurology, 505 Parnassus Ave, Box 0114, San Francisco, California 94143 (andrew.josephson@ucsf.edu).

Published Online: April 10, 2020. doi:10.1001/jamaneurol.2020.1065

Correction: This article was corrected on June 8, 2020, to add an additional reference.

Conflict of Interest Disclosures: Dr Pleasure received grants from National Institute of Mental Health, the Weill Institute for Neuroscience, the Brain Research Foundation, and the George and Judy Marcus Fund for Innovation. Dr Green reported personal fees from Viela Bio, Mylan, Bionure, and Neurona; other support from Pipeline Therapeutics; and grants and other support from Inception Sciences outside the submitted work. Dr Josephson reported personal fees from JAMA Neurology and personal fees from Continuum Audio outside the submitted work. No other disclosures were reported.

References
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