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Caution Needed on the Use of Chloroquine and Hydroxychloroquine for Coronavirus Disease 2019

Educational Objective
To understand the need for rigorous testing regarding potential treatments for COVID-19
1 Credit CME

The coronavirus disease 2019 (COVID-19) pandemic has propagated global shock waves that have disrupted nearly every aspect of human endeavor. Nowhere has this been more evident than in health care. Health care delivery systems in some locations have been overwhelmed, and even those not so severely affected have had to reorganize and restructure to concentrate resources to meet an anticipated surge of patients who are critically ill. In the absence of rapid and reliable testing, proven therapies, or even standard protocols for treatment, physicians and other clinicians have been forced to improvise, in some cases relying on the thinnest of evidence, to treat patients who are desperately ill.

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Article Information

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Fihn SD et al. JAMA Network Open.

Published: April 24, 2020. doi:10.1001/jamanetworkopen.2020.9035

Correction: This article was corrected on April 27, 2020, to fix an incorrect drug name in the third paragraph.

Corresponding Author: Stephan D. Fihn, MD, MPH, Department of Medicine, Harborview Medical Center, University of Washington, 325 Ninth Ave, PO Box 359780, Seattle, WA 98104 (sfihn@uw.edu).

Conflict of Interest Disclosures: None reported.

Disclaimer: The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government.

References
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Gautret  P , Lagier  J-C , Parola  P ,  et al.  Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.   Int J Antimicrob Agents. March 2020:105949. doi:10.1016/j.ijantimicag.2020.105949PubMedGoogle Scholar
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