[Skip to Content]
Outline
Claim CME
PDF
Pregnancy

Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection

Educational Objective
To understand COVID-19 as a possible contributor to a second-trimester miscarriage
1 Credit CME
JAMA
Published Online: April 30, 2020
Research Letter
David Baud, MD, PhD1;
Gilbert Greub, MD, PhD2;
Guillaume Favre, MD1;
Carole Gengler, MD3;
Katia Jaton, PhD2;
Estelle Dubruc, MD3;
Léo Pomar, MSc1
Author Affiliations
  • 1Department Woman-Mother-Child, Lausanne University Hospital, Lausanne, Switzerland
  • 2Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland
  • 3Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland
Read article on JAMA Network

MOC/CME Information

editorial comment icon
Editorial
Comment
 related articles icon
Related
Articles
 author interview icon
Interviews
 multimedia icon
Multimedia
Read Article Claim CME

No data exist regarding the effect on fetuses of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the first or second trimester of pregnancy, and data are limited regarding infections that occur during the third trimester. However, reports of newborns with fetal distress or requiring admission to the intensive care unit1,2 and a stillbirth after maternal coronavirus disease 2019 (COVID-19)3 in the third trimester suggest the possibility of COVID-19–induced placental pathology.

Sign in to take quiz and track your certificates

Buy This Activity
Our websites may be periodically unavailable between 12:00am CT March 25, 2023 and 4:00pm CT March 26, 2023 for regularly scheduled maintenance.

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 Credit(s)™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

Related Articles

  1. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Newborns Born to Mothers With COVID-19 in Wuhan, China
    1.00 CME

  2. Can SARS-CoV-2 Infection Be Acquired In Utero?
    1.00 CME

  3. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn
    1.00 CME

  4. Labor and Delivery Visitor Policies During the COVID-19 Pandemic
    1.00 CME

  5. Prevalence of SARS-CoV-2 Among Patients Admitted for Childbirth in Southern Connecticut
    1.00 CME

  6. Caring for Women Who Are Planning Pregnancy, Pregnant, or Postpartum During the COVID-19 Pandemic
    1.00 CME

  7. Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic
    1.00 CME

  8. Association Between In-Person Health Care Visits and SARS-CoV-2 Infection in Obstetrical Patients
    1.00 CME

  9. Association of SARS-CoV-2 Test Status and Pregnancy Outcomes

  10. Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes
    1.00 CME

See More

CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

See More About

Pregnancy Obstetrics Women's Health Obstetrics and Gynecology Coronavirus (COVID-19)
Article Information

Corresponding Author: David Baud, MD, PhD, Materno-fetal and Obstetrics Research Unit, Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Vaudois (CHUV), 1011 Lausanne, Switzerland (david.baud@chuv.ch).

Accepted for Publication: April 20, 2020.

Published Online: April 30, 2020. doi:10.1001/jama.2020.7233

Author Contributions: Dr Baud had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Baud, Favre, Jaton, Pomar.

Acquisition, analysis, or interpretation of data: Baud, Greub, Favre, Gengler, Dubruc, Pomar.

Drafting of the manuscript: Baud, Favre, Jaton, Pomar.

Critical revision of the manuscript for important intellectual content: Baud, Greub, Favre, Gengler, Dubruc, Pomar.

Administrative, technical, or material support: All authors.

Supervision: Baud, Greub.

Conflict of Interest Disclosures: Dr Greub reported having ongoing research agreements with Resistell and Becton-Dickinson and being medical advisor for Resistell; he also reported being developer of a card game on microbes and funding JeuPro, a start-up company that distributes the game Krobs. No other disclosures were reported.

References
1.
Chen  H , Guo  J , Wang  C ,  et al.  Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.   Lancet. 2020;395(10226):809-815. doi:10.1016/S0140-6736(20)30360-3PubMedGoogle ScholarCrossref
2.
Zhu  H , Wang  L , Fang  C ,  et al.  Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia.   Transl Pediatr. 2020;9(1):51-60. doi:10.21037/tp.2020.02.06PubMedGoogle ScholarCrossref
3.
Liu  Y , Chen  H , Tang  K , Guo  Y .  Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy.   J Infect. 2020;S0163-4453(20)30109-2. doi:10.1016/j.jinf.2020.02.028PubMedGoogle Scholar
4.
Kimberlin  DW , Stagno  S .  Can SARS-CoV-2 infection be acquired in utero? more definitive evidence is needed.   JAMA. Published online March 26, 2020. doi:10.1001/jama.2020.4868PubMedGoogle Scholar
5.
Favre  G , Pomar  L , Musso  D , Baud  D .  2019-nCoV epidemic: what about pregnancies?   Lancet. 2020;395(10224):e40. doi:10.1016/S0140-6736(20)30311-1PubMedGoogle Scholar
6.
Wong  SF , Chow  KM , Leung  TN ,  et al.  Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome.   Am J Obstet Gynecol. 2004;191(1):292-297. doi:10.1016/j.ajog.2003.11.019PubMedGoogle ScholarCrossref
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

Close
Want full access to the AMA Ed Hub?
Become an AMA member now
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
Want full access to the AMA Ed Hub?
Become an AMA member now
After you sign up for AMA Membership, make sure you sign in or create a Physician account with the AMA in order to access all learning activities on the AMA Ed Hub
Buy this activity
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Close
Close

Lookup An Activity

or

My Saved Searches

You currently have no searches saved.

Close

My Saved Courses

You currently have no courses saved.

Close
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue