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Hydroxychloroquine, Coronavirus Disease 2019, and QT Prolongation

Educational Objective
To understand the risks of QT Prolongation when prescribing hydroxychloroquine
1 Credit CME

The complex decisions facing clinical teams caring for patients who are critically ill with coronavirus disease 2019 (COVID-19) are compounded by the absence of proven treatment strategies. Lacking robust trial evidence, clinicians are forced to consider all options based on preclinical and small observational studies, often in heart-wrenching settings of patients who are deteriorating in the throes of severe pneumonia, acute respiratory distress syndrome, cytokine storm, and in many cases, cardiovascular complications.

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Article Information

Corresponding Author: Robert O. Bonow, MD, MS, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Ste 600, Chicago, IL 60611 (robert.bonow@nm.org).

Published Online: May 1, 2020. doi:10.1001/jamacardio.2020.1782

Conflict of Interest Disclosures: Dr Hernandez reported receiving funds from the Patient-Centered Outcome Research Institute for a clinical trial of hydroxychloroquine to evaluate the efficacy of preexposure prophylaxis among health care workers. Dr Turakhia reported grants from Apple Inc and the American Heart Association and other support from AliveCor outside the submitted work. No other disclosures were reported.

References
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Bessière  F , Roccia  H , Delinière  A ,  et al.  Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit.   JAMA Cardiol. Published online May 1, 2020. doi:10.1001/jamacardio.2020.1787Google Scholar
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