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Infectious Diseases

Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019

Educational Objective
To understand the prevalence of SARS-COV-2 in semen among men with COVID-19

1 Credit CME

JAMA Network Open

Published Online: May 7, 2020

Research Letter

Article Information and Disclosures

Diangeng Li, PhD^1,2;

Meiling Jin, MD^2,3;

Pengtao Bao, PhD⁴;

Weiguo Zhao, MD⁴;

Shixi Zhang, MD⁵

Author Affiliations

¹Nanlou Respiratory Diseases Department, Chinese People’s Liberation Army General Hospital, Beijing, China
²Department of Nephrology, Chinese People’s Liberation Army General Hospital, Chinese People’s Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Chinese People’s Liberation Army Postgraduate Medical School, Beijing, China
³Department of Nephrology, Beijing-Chaoyang Hospital, Beijing, China
⁴Department of Respiratory Medicine, The Eighth Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, China
⁵Shangqiu Municipal Hospital, Shangqiu, China

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In December 2019, an outbreak of pneumonia associated with coronavirus disease 2019 (COVID-19) occurred in Wuhan, China, and rapidly spread to other parts of China and overseas.¹ It has been confirmed that COVID-19 has the characteristic of human-to-human transmission, mainly through respiratory droplets and contact. Other routes require further verification. The virus responsible for COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in stool, gastrointestinal tract, saliva, and urine samples.² However, little is known about SARS-CoV-2 in semen.

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Article Information

Accepted for Publication: April 13, 2020.

Published: May 7, 2020. doi:10.1001/jamanetworkopen.2020.8292

Correction: This article was corrected on June 1, 2020, to fix an omission in the Methods.

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Li D et al. JAMA Network Open.

Corresponding Authors: Weiguo Zhao, MD, Department of Respiratory Medicine, The Eighth Medical Center of Chinese People’s Liberation Army General Hospital, 17th Heishanhu Road, Beijing, 100093, China (zhaowg309@163.com); Shixi Zhang, MD, Shangqiu Municipal Hospital, Shangqiu, No. 1 Yingbin Road, Shangqiu City, Henan Province, China, 476100, China (Shixizhang1977@163.com).

Author Contributions: Drs Zhao and Zhang had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Li, Jin, and Bao contributed equally to this work.

Concept and design: Li, Jin, Zhao, Zhang.

Acquisition, analysis, or interpretation of data: Li, Jin, Bao.

Drafting of the manuscript: Li, Jin.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Li, Jin, Bao.

Obtained funding: Li, Jin.

Administrative, technical, or material support: Li, Zhao, Zhang.

Conflict of Interest Disclosures: None reported.

Funding/Support: This study was partially supported by grant KF2018-06 from the Open Project Program of the State Key Laboratory of Kidney Diseases in People’s Liberation Army General Hospital.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References

Huang C , Wang Y , Li X , et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5 PubMed Google Scholar Crossref

Guan W , Ni Z-y , Hu Y , et al; China Medical Treatment Expert Group for Covid-19. Clinical characteristics of 2019 novel coronavirus infection in China. N Engl J Med. Published online February 28, 2020. doi:10.1056/NEJMoa2002032 PubMed Google Scholar

World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191-2194. doi:10.1001/jama.2013.281053.Google Scholar Crossref

World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance, 25 January 2020. Accessed April 14, 2020. https://apps.who.int/iris/handle/10665/330854.

Mead PS , Duggal NK , Hook SA , et al. Zika virus shedding in semen of symptomatic infected men. N Engl J Med. 2018;378(15):1377-1385. doi:10.1056/NEJMoa1711038 PubMed Google Scholar Crossref

Feldmann H . Virus in semen and the risk of sexual transmission. N Engl J Med. 2018;378(15):1440-1441. doi:10.1056/NEJMe1803212 PubMed Google Scholar Crossref

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.