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Coronavirus Disease 2019 Test Results After Clinical Recovery and Hospital Discharge Among Patients in China

Educational Objective
To understand the importance of assessing the COVID-19 infected patient’s health and recovery period after being discharged
1 Credit CME

Coronavirus disease 2019 (COVID-19) spreads rapidly between cities and internationally via person-to-person transmission.1 Persistence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid has been demonstrated in patients who have clinically recovered,2 but the overall prognosis of patients with COVID-19 after meeting the criteria for hospital discharge has not been reported, to our knowledge.

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Article Information

Accepted for Publication: April 25, 2020.

Published: May 22, 2020. doi:10.1001/jamanetworkopen.2020.9759

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Wu J et al. JAMA Network Open.

Corresponding Author: Pa Wu, PhD, College of Life Science, Hunan Normal University, No. 36, Lushan South Rd., Changsha 410081, China (wupa@hunnu.edu.cn).

Author Contributions: Mr J. Wu and Dr P. Wu had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: J. Wu, P. Wu.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: J. Wu, P. Wu.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: J. Wu, X. Liu, P. Wu.

Obtained funding: P. Wu.

Administrative, technical, or material support: Zhou.

Supervision: J. Wu, P. Wu.

Conflict of Interest Disclosures: None reported.

Funding/Support: This work was supported by grants No. 81902094 and 81600497 from the National Natural Science Foundation of China (Dr Zhou) and grant No. 2019RS1036 from the Science and Technology Plan Project of Hunan Province (Dr P. Wu).

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
1.
Chan  JF , Yuan  S , Kok  KH ,  et al.  A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.   Lancet. 2020;395(10223):514-523. doi:10.1016/S0140-6736(20)30154-9 PubMedGoogle ScholarCrossref
2.
Lan  L , Xu  D , Ye  G ,  et al.  Positive RT-PCR test results in patients recovered from COVID-19.   JAMA. 2020;323(15):1502-1503. doi:10.1001/jama.2020.2783 PubMedGoogle ScholarCrossref
3.
China National Health Commission. Diagnosis and treatment of 2019-nCoV pneumonia in China [in Chinese]. Published February 18, 2020. Accessed April 28, 2020. http://www.nhc.gov.cn/yzygj/s7653p/202002/8334a8326dd94d329df351d7da8aefc2/files/b218cfeb1bc54639af227f922bf6b817.pdf
4.
Xing  Y-H , Ni  W , Wu  Q ,  et al.  Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019.   J Microbiol Immunol Infect. 2020;1182(1620):30081-30085. doi:10.1016/j.jmii.2020.03.021PubMedGoogle Scholar
5.
Wölfel  R , Corman  VM , Guggemos  W ,  et al.  Virological assessment of hospitalized patients with COVID-2019.   Nature. Published online April 1, 2020. doi:10.1038/s41586-020-2196-xPubMedGoogle Scholar
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