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Nasal ACE2 Levels and COVID-19 in Children

Educational Objective
To understand how ACE2 may affect children’s susceptibility to COVID-19
1 Credit CME

Coronavirus disease 2019 (COVID-19) has disproportionately affected certain vulnerable populations. Studies noted higher rates of certain comorbidities such as hypertension, diabetes mellitus, and chronic obstructive pulmonary disease in patients infected with COVID-19 with severe disease.1 Additionally, areas with more racial/ethnic minorities and higher rates of poverty have been shown to have higher rates of COVID-19 hospitalization and death.2 After adjustment for comorbidities, age has been independently associated with increased mortality due to COVID-19.3 However, limited attention has been given to children, who appear to have lower risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality.

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Article Information

Corresponding Author: Ankit B. Patel, MD, PhD, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02132 (apatel38@bwh.harvard.edu).

Published Online: May 20, 2020. doi:10.1001/jama.2020.8946

Conflict of Interest Disclosures: Dr Patel reported receipt of grants from Relypsa and consulting fees from Third Rock Ventures. No other disclosures were reported.

References
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