Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults | Infectious Diseases | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

Educational Objective
To understand how the differences in Angiotensin-Converting Enzyme 2 Between children and adults can explain differences in COVID-19 susceptibility
1 Credit CME

Children account for less than 2% of identified cases of coronavirus disease 2019 (COVID-19).1,2 It is hypothesized that the lower risk among children is due to differential expression of angiotensin-converting enzyme 2 (ACE2),3 the receptor that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses for host entry.4 We investigated ACE2 gene expression in the nasal epithelium of children and adults.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 CME Credit™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

Article Information

Corresponding Author: Supinda Bunyavanich, MD, MPH, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave #1498, New York, NY 10029 (supinda@post.harvard.edu).

Accepted for Publication: May 7, 2020.

Published Online: May 20, 2020. doi:10.1001/jama.2020.8707

Author Contributions: Dr Bunyavanich had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: Bunyavanich, Do.

Drafting of the manuscript: Bunyavanich.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Bunyavanich, Do.

Obtained funding: Bunyavanich.

Administrative, technical, or material support: Bunyavanich.

Supervision: Bunyavanich, Vicencio.

Conflict of Interest Disclosures: Dr Vicencio reported being an investor in Filament Biosolutions. No other disclosures were reported.

Funding/Support: This study was funded by National Institutes of Health grant R01 AI118833.

Role of the Funder/Sponsor: The funding organization had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.

Additional Contributions: We thank Robert Griffin, MD, PhD, Hospital for Special Surgery, and Yoojin Chun, MS, Icahn School of Medicine at Mount Sinai, for their assistance with manuscript preparation. Dr Griffin and Ms Chun did not receive compensation for their contributions.

References
1.
Wu  Z , McGoogan  JM .  Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention.   JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.2648PubMedGoogle ScholarCrossref
2.
CDC COVID-19 Response Team.  Coronavirus disease 2019 in children—United States, February 12–April 2, 2020.   MMWR Morb Mortal Wkly Rep. 2020;69(14):422-426. doi:10.15585/mmwr.mm6914e4PubMedGoogle ScholarCrossref
3.
Dong  Y , Mo  X , Hu  Y ,  et al.  Epidemiology of COVID-19 among children in China.   Pediatrics. 2020;145(4):e20200702. doi:10.1542/peds.2020-0702PubMedGoogle Scholar
4.
Hoffmann  M , Kleine-Weber  H , Schroeder  S ,  et al.  SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor.   Cell. 2020;181(2):271-280.e8. doi:10.1016/j.cell.2020.02.052PubMedGoogle ScholarCrossref
5.
Schouten  LR , van Kaam  AH , Kohse  F ,  et al; MARS Consortium.  Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study.   Ann Intensive Care. 2019;9(1):55. doi:10.1186/s13613-019-0529-4PubMedGoogle ScholarCrossref
6.
Chun  Y , Do  A , Grishina  G ,  et al.  Integrative study of the upper and lower airway microbiome and transcriptome in asthma.   JCI Insight. 2020;5(5):e133707. doi:10.1172/jci.insight.133707PubMedGoogle Scholar
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_Multimedia_LoginSubscribe_Purchase
Close
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_Multimedia_LoginSubscribe_Purchase
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
jn-learning_Modal_SaveSearch_NoAccess_Purchase
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close