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Infectious Diseases

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

Educational Objective
To understand how the differences in Angiotensin-Converting Enzyme 2 Between children and adults can explain differences in COVID-19 susceptibility

1 Credit CME

JAMA

Published Online: May 20, 2020

Research Letter

Article Information and Disclosures

Supinda Bunyavanich, MD, MPH¹;

Alfin Vicencio, MD¹

Author Affiliations

¹Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York
²Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York

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Article Information

Corresponding Author: Supinda Bunyavanich, MD, MPH, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave #1498, New York, NY 10029 (supinda@post.harvard.edu).

Accepted for Publication: May 7, 2020.

Published Online: May 20, 2020. doi:10.1001/jama.2020.8707

Author Contributions: Dr Bunyavanich had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Acquisition, analysis, or interpretation of data: Bunyavanich, Do.

Drafting of the manuscript: Bunyavanich.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Bunyavanich, Do.

Obtained funding: Bunyavanich.

Administrative, technical, or material support: Bunyavanich.

Supervision: Bunyavanich, Vicencio.

Conflict of Interest Disclosures: Dr Vicencio reported being an investor in Filament Biosolutions. No other disclosures were reported.

Funding/Support: This study was funded by National Institutes of Health grant R01 AI118833.

Role of the Funder/Sponsor: The funding organization had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.

Additional Contributions: We thank Robert Griffin, MD, PhD, Hospital for Special Surgery, and Yoojin Chun, MS, Icahn School of Medicine at Mount Sinai, for their assistance with manuscript preparation. Dr Griffin and Ms Chun did not receive compensation for their contributions.

References

Wu Z , McGoogan JM . Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.2648 PubMed Google Scholar Crossref

CDC COVID-19 Response Team. Coronavirus disease 2019 in children—United States, February 12–April 2, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(14):422-426. doi:10.15585/mmwr.mm6914e4 PubMed Google Scholar Crossref

Dong Y , Mo X , Hu Y , et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145(4):e20200702. doi:10.1542/peds.2020-0702 PubMed Google Scholar

Hoffmann M , Kleine-Weber H , Schroeder S , et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271-280.e8. doi:10.1016/j.cell.2020.02.052 PubMed Google Scholar Crossref

Schouten LR , van Kaam AH , Kohse F , et al; MARS Consortium. Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. Ann Intensive Care. 2019;9(1):55. doi:10.1186/s13613-019-0529-4 PubMed Google Scholar Crossref

Chun Y , Do A , Grishina G , et al. Integrative study of the upper and lower airway microbiome and transcriptome in asthma. JCI Insight. 2020;5(5):e133707. doi:10.1172/jci.insight.133707 PubMed Google Scholar

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.