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Translating Science on COVID-19 to Improve Clinical Care and Support the Public Health Response

Educational Objective
To understand how to translate scientific discoveries about COVID-19 into actionable items for Health Care Workers and Public Health Responses
1 Credit CME

Now in its fifth month, the coronavirus disease 2019 (COVID-19) pandemic continues to advance with nearly 5 million documented infections worldwide and with the US having the largest number of infections and deaths globally. The speed of the scientific response to the epidemic has been unprecedented. On January 7, Chinese investigators identified a novel coronavirus as the cause of an unusual cluster of pneumonia cases, and 5 days later the virus genetic sequence was published. By February 21, the first treatment trial had been initiated and March 18 marked the start of the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine trial in humans. The time from the initial viral sequencing to the first in human injection of a candidate vaccine was a record 65 days.

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Article Information

Corresponding Author: Carlos del Rio, MD, Emory University School of Medicine, 49 Jesse Hill Jr Dr, FOB Room 201, Atlanta, GA 30303 (cdelrio@emory.edu).

Published Online: May 22, 2020. doi:10.1001/jama.2020.9252

Conflict of Interest Disclosures: Dr del Rio reported receiving grants from the National Institutes of Health/National Institute of Allergy and Infectious Diseases. No other disclosures were reported.

References
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National Institute of Infectious Diseases. NIH clinical trial shows remdesivir accelerates recovery from advanced COVID-19. Published April 29, 2020. Accessed May 10, 2020. https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19
2.
Omer  SB , Malani  P , Del Rio  C .  The COVID-19 pandemic in the US: a clinical update.   JAMA. Published online April 6, 2020. doi:10.1001/jama.2020.5788PubMedGoogle Scholar
3.
COVID-19 Treatment Guidelines Panel. Coronavirus disease 2019 (COVID-19) treatment guidelines. Updated May 12, 2020. Accessed May 21, 2020. National Institutes of Health. https://www.covid19treatmentguidelines.nih.gov/
4.
Bhimraj  A , Morgan  RL , Shumaker  AH ,  et al. Infectious Diseases Society of America guidelines on the treatment and management of patients with COVID-19. Published April 11, 2020. Accessed May 11, 2020. https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management
5.
Gilead announces results from phase 3 trial of investigational antiviral remdesivir in patients with severe COVID-19. Published April 29, 2020. Accessed May 12, 2020. https://www.gilead.com/news-and-press/press-room/press-releases/2020/4/gilead-announces-results-from-phase-3-trial-of-investigational-antiviral-remdesivir-in-patients-with-severe-covid-19
6.
Rosenberg  ES , Dufort  EM , Udo  T ,  et al.  Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York state.   JAMA. Published online May 11, 2020. doi:10.1001/jama.2020.8630 PubMedGoogle Scholar
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Persad  G , Emanuel  EJ .  The ethics of COVID-19 immunity-based licenses (“Immunity Passports”).   JAMA. Published online May 6, 2020. doi:10.1001/jama.2020.8102PubMedGoogle Scholar
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9.
Walensky  RP , Del Rio  C .  From mitigation to containment of the COVID-19 pandemic: putting the SARS-CoV-2 genie back in the bottle.   JAMA. Published online April 17, 2020. doi:10.1001/jama.2020.6572PubMedGoogle Scholar
10.
Yancy  CW .  COVID-19 and African Americans.   JAMA. Published online April 15, 2020. doi:10.1001/jama.2020.6548 PubMedGoogle Scholar
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