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Sepsis

SARS-CoV-2–Related Inflammatory Multisystem Syndrome in ChildrenDifferent or Shared Etiology and Pathophysiology as Kawasaki Disease?

Educational Objective
To understand the similarities between the inflammatory multisystem syndrome and Kawasaki disease

1 Credit CME

JAMA

Published Online: June 8, 2020

Editorial

Article Information and Disclosures

Brian W. McCrindle, MD, MPH¹;

Cedric Manlhiot, PhD²

Author Affiliations

¹Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
²Johns Hopkins University School of Medicine, Division of Cardiology, Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland

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Original Investigation

Clinical Characteristics of Children With SARS-CoV-2–Associated Pediatric Inflammatory Multisystem Syndrome

Elizabeth Whittaker, MD; Alasdair Bamford, MD; Julia Kenny, MD; Myrsini Kaforou, PhD; Christine E. Jones, MD; Priyen Shah, MD; Padmanabhan Ramnarayan, MD; Alain Fraisse, MD; Owen Miller, MD; Patrick Davies, MD; Filip Kucera, MD; Joe Brierley, MD; Marilyn McDougall, MD; Michael Carter, MD; Adriana Tremoulet, MD; Chisato Shimizu, MD; Jethro Herberg, MD; Jane C. Burns, MD; Hermione Lyall, MD; Michael Levin, MD; for the PIMS-TS Study Group and EUCLIDS and PERFORM Consortia
Research Letter

Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents

Eva W. Cheung, MD; Philip Zachariah, MD, MS; Mark Gorelik, MD; Alexis Boneparth, MD; Steven G. Kernie, MD; Jordan S. Orange, MD, PhD; Joshua D. Milner, MD
Original Investigation

Characteristics and Outcomes of US Children and Adolescents With MIS-C Compared With Severe Acute COVID-19

Leora R. Feldstein, PhD; Mark W. Tenforde, MD; Kevin G. Friedman, MD; Margaret Newhams, MPH; Erica Billig Rose, PhD; Heda Dapul, MD; Vijaya L. Soma, MD; Aline B. Maddux, MD; Peter M. Mourani, MD; Cindy Bowens, MD; Mia Maamari, MD; Mark W. Hall, MD; Becky J. Riggs, MD; John S. Giuliano Jr, MD; Aalok R. Singh, MD; Simon Li, MD; Michele Kong, MD; Jennifer E. Schuster, MD; Gwenn E. McLaughlin, MD; Stephanie P. Schwartz, MD; Tracie C. Walker, MD; Laura L. Loftis, MD; Charlotte V. Hobbs, MD; Natasha B. Halasa, MD; Sule Doymaz, MD; Christopher J. Babbitt, MD; Janet R. Hume, MD; Shira J. Gertz, MD; Katherine Irby, MD; Katharine N. Clouser, MD; Natalie Z. Cvijanovich, MD; Tamara T. Bradford, MD; Lincoln S. Smith, MD; Sabrina M. Heidemann, MD; Sheemon P. Zackai, MD; Kari Wellnitz, MD; Ryan A. Nofziger, MD; Steven M. Horwitz, MD; Ryan W. Carroll, MD; Courtney M. Rowan, MD; Keiko M. Tarquinio, MD; Elizabeth H. Mack, MD; Julie C. Fitzgerald, MD; Bria M. Coates, MD; Ashley M. Jackson, MPH; Cameron C. Young; Mary Beth F. Son, MD; Manish M. Patel, MD; Jane W. Newburger, MD; Adrienne G. Randolph, MD; Overcoming COVID-19 Investigators

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The pediatric inflammatory multisystem syndrome (PIMS) now described in association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has generated considerable interest, both for its severity and delayed emergence in an age group largely spared the complications of primary infection, but also for its overlapping clinical features with Kawasaki disease (KD), the leading cause of acquired heart disease in children in high-income countries.¹ This has prompted considerable discussion that the 2 conditions could have different or shared etiologic and pathophysiologic pathways.

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Article Information

Corresponding Author: Brian W. McCrindle, MD, MPH, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, ON M5G 1X8, Canada (brian.mccrindle@sickkids.ca).

Published Online: June 8, 2020. doi:10.1001/jama.2020.10370

Conflict of Interest Disclosures: Dr McCrindle reported receiving personal fees from Janssen and serving as an investigator for Janssen and Mezzion. No other disclosures were reported.

References

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Whittaker E , Bamford A , Kenny J , et al; PIMS-TS Study Group; EUCLIDS and PERFORM Consortia. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA. Published online June 8, 2020. doi:10.1001/jama.2020.10369 Google Scholar

Cheung EW , Zachariah P , Gorelik M , et al. Multisystem inflammatory syndrome related to COVID-19 in previously healthy children and adolescents in New York City. JAMA. Published online June 8, 2020. doi:10.1001/jama.2020.10374 Google Scholar

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AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.