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SARS-CoV-2–Related Inflammatory Multisystem Syndrome in ChildrenDifferent or Shared Etiology and Pathophysiology as Kawasaki Disease?

Educational Objective
To understand the similarities between the inflammatory multisystem syndrome and Kawasaki disease
1 Credit CME

The pediatric inflammatory multisystem syndrome (PIMS) now described in association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has generated considerable interest, both for its severity and delayed emergence in an age group largely spared the complications of primary infection, but also for its overlapping clinical features with Kawasaki disease (KD), the leading cause of acquired heart disease in children in high-income countries.1 This has prompted considerable discussion that the 2 conditions could have different or shared etiologic and pathophysiologic pathways.

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Article Information

Corresponding Author: Brian W. McCrindle, MD, MPH, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, ON M5G 1X8, Canada (brian.mccrindle@sickkids.ca).

Published Online: June 8, 2020. doi:10.1001/jama.2020.10370

Conflict of Interest Disclosures: Dr McCrindle reported receiving personal fees from Janssen and serving as an investigator for Janssen and Mezzion. No other disclosures were reported.

References
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