Donated convalescent plasma may be beneficial to patients with severe coronavirus disease 2019 (COVID-19) to boost their ability to fight the virus.
Most people who recover from COVID-19 develop antibodies (proteins that the immune system produces in response to infection) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Antibodies are found in plasma, the yellow liquid portion of blood. Plasma is collected from donors who have recovered from COVID-19 through a process called apheresis, which uses a special machine to separate the blood into different components. The plasma is removed, while the rest of the blood components are returned into the donor’s body.
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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Published Online: June 12, 2020. doi:10.1001/jama.2020.10699
Conflict of Interest Disclosures: None reported.
Sources: Fung MK, Eder A, Spitalnik SL, Westhoff CM, eds. Technical Manual. 19th ed. AABB Press; 2017.
US Food and Drug Administration. Recommendations for investigational COVID-19 convalescent plasma. www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/recommendations-investigational-covid-19-convalescent-plasma
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