Preliminary Communication

Treatment of Critically Ill Patients With COVID-19 With Convalescent Plasma

Chenguang Shen, PhD; Zhaoqin Wang, PhD; Fang Zhao, PhD; Yang Yang, MD; Jinxiu Li, MD; Jing Yuan, MD; Fuxiang Wang, MD; Delin Li, PhD; Minghui Yang, PhD; Li Xing, MM; Jinli Wei, MM; Haixia Xiao, PhD; Yan Yang, MM; Jiuxin Qu, MD; Ling Qing, MM; Li Chen, MD; Zhixiang Xu, MM; Ling Peng, MM; Yanjie Li, MM; Haixia Zheng, MM; Feng Chen, MM; Kun Huang, MM; Yujing Jiang, MM; Dongjing Liu, MD; Zheng Zhang, MD; Yingxia Liu, MD; Lei Liu, MD
Medical News & Perspectives

Testing an Old Therapy Against a New Disease: Convalescent Plasma for COVID-19

Rita Rubin, MA
Original Investigation

Convalescent Plasma Therapy and Clinical Improvement in Severe and Life-threatening COVID-19

Ling Li, MD, PhD; Wei Zhang, MD; Yu Hu, MD, PhD; Xunliang Tong, MD, PhD; Shangen Zheng, MD; Juntao Yang, PhD; Yujie Kong, MD; Lili Ren, PhD; Qing Wei, MD; Heng Mei, MD, PhD; Caiying Hu, MD; Cuihua Tao, MD; Ru Yang, MD; Jue Wang, MD; Yongpei Yu, PhD; Yong Guo, PhD; Xiaoxiong Wu, MD; Zhihua Xu, MD; Li Zeng, MD; Nian Xiong, MD, PhD; Lifeng Chen, MD; Juan Wang, MD; Ning Man, MD; Yu Liu, PhD; Haixia Xu, MD; E. Deng, MS; Xuejun Zhang, MS; Chenyue Li, MD; Conghui Wang, PhD; Shisheng Su, PhD; Linqi Zhang, PhD; Jianwei Wang, PhD; Yanyun Wu, MD, PhD; Zhong Liu, MD, PhD
JAMA Patient Page

Patient Information: Caring for Someone With COVID-19

Lindsey Y. Mortenson, MD; Preeti N. Malani, MD, MSJ; Robert D. Ernst, MD
Original Investigation

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19

Perrine Janiaud, PhD; Cathrine Axfors, MD, PhD; Andreas M. Schmitt, MD; Viktoria Gloy, PhD; Fahim Ebrahimi, MD, MSc; Matthias Hepprich, MD; Emily R. Smith, ScD, MPH; Noah A. Haber, ScD; Nina Khanna, MD; David Moher, PhD; Steven N. Goodman, MD, PhD; John P. A. Ioannidis, MD, DSc; Lars G. Hemkens, MD, MPH

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Donated convalescent plasma may be beneficial to patients with severe coronavirus disease 2019 (COVID-19) to boost their ability to fight the virus.

Most people who recover from COVID-19 develop antibodies (proteins that the immune system produces in response to infection) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Antibodies are found in plasma, the yellow liquid portion of blood. Plasma is collected from donors who have recovered from COVID-19 through a process called apheresis, which uses a special machine to separate the blood into different components. The plasma is removed, while the rest of the blood components are returned into the donor’s body.

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Article Information

Published Online: June 12, 2020. doi:10.1001/jama.2020.10699

Conflict of Interest Disclosures: None reported.

Sources: Fung MK, Eder A, Spitalnik SL, Westhoff CM, eds. Technical Manual. 19th ed. AABB Press; 2017.

US Food and Drug Administration. Recommendations for investigational COVID-19 convalescent plasma. www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/recommendations-investigational-covid-19-convalescent-plasma

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Hopeful Signals From a Randomized Trial of Convalescent Plasma to Treat COVID-19

Convalescent Plasma Therapy and Clinical Improvement in Severe and Life-threatening COVID-19

Patient Information: Caring for Someone With COVID-19

Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19

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