Colchicine for the Treatment of Myocardial Injury in Patients With COVID-19 | Infectious Diseases | JN Learning | AMA Ed Hub [Skip to Content]
[Skip to Content Landing]

Colchicine for the Treatment of Myocardial Injury in Patients With Coronavirus Disease 2019 (COVID-19)—An Old Drug With New Life?

Educational Objective
To understand how COVID-19 has given Colchicine new life as a form of treatment of myocardial injury
1 Credit CME

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 6 million individuals worldwide, leading to the ongoing coronavirus disease 2019 (COVID-19) pandemic and significant morbidity and mortality. Patients with active myocardial injury (ie, elevated troponin levels) are at a very high risk, with mortality rates reaching as high as 40%.1,2 In particular, the subset of patients with evidence of myocardial injury and underlying cardiovascular disease are at exceedingly high risk, with mortality rates of nearly 70%.1,2 While several mechanisms have been postulated for how SARS-CoV-2 may damage the lungs, heart, and other organs, indirect damage from innate, cellular, and/or humoral immune responses, including a severe cytokine storm, is a leading hypothesis supported by numerous studies reporting significantly elevated inflammatory biomarkers in patients with COVID-19.

Sign in to take quiz and track your certificates

Buy This Activity

JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 CME Credit™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC

Article Information

Published: June 24, 2020. doi:10.1001/jamanetworkopen.2020.13556

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Rabbani AB et al. JAMA Network Open.

Corresponding Author: Amir B. Rabbani, MD, Division of Cardiology, University of California, Los Angeles, 3500 Lomita Blvd, Ste M100, Torrance, CA 90505 (arabbani@mednet.ucla.edu).

Conflict of Interest Disclosures: None reported.

References
1.
Guo  T , Fan  Y , Chen  M ,  et al.  Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19).   JAMA Cardiol. Published online March 27, 2020. doi:10.1001/jamacardio.2020.1017PubMedGoogle Scholar
2.
Deng  Y , Liu  W , Liu  K ,  et al.  Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study.   Chin Med J (Engl). Published March 20, 2020. doi:10.1097/CM9.0000000000000824PubMedGoogle Scholar
3.
Leung  YY , Yao Hui  LL , Kraus  VB .  Colchicine—update on mechanisms of action and therapeutic uses.   Semin Arthritis Rheum. 2015;45(3):341-350. doi:10.1016/j.semarthrit.2015.06.013PubMedGoogle ScholarCrossref
4.
Imazio  M , Bobbio  M , Cecchi  E ,  et al.  Colchicine in addition to conventional therapy for acute pericarditis: results of the Colchicine for Acute Pericarditis (COPE) trial.   Circulation. 2005;112(13):2012-2016. doi:10.1161/CIRCULATIONAHA.105.542738PubMedGoogle ScholarCrossref
5.
Imazio  M , Cecchi  E , Trinchero  R ; COPPS Investigators.  Colchicine for the prevention of the postpericardiotomy syndrome: the COPPS trial.   Int J Cardiol. 2007;121(2):198-199. doi:10.1016/j.ijcard.2006.08.071PubMedGoogle ScholarCrossref
6.
Tardif  JC , Kouz  S , Waters  DD ,  et al.  Efficacy and safety of low-dose colchicine after myocardial infarction.   N Engl J Med. 2019;381(26):2497-2505. doi:10.1056/NEJMoa1912388PubMedGoogle ScholarCrossref
7.
Deftereos  SG , Giannopoulos  G , Vrachatis  DA ,  et al; GRECCO-19 Investigators.  Effect of colchicine vs standard care on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019: the GRECCO-19 randomized clinical trial.   JAMA Netw Open. 2020;3(6):e2013136. doi:10.1001/jamanetworkopen.2020.13136Google Scholar
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_Multimedia_LoginSubscribe_Purchase
Close
If you are not a JN Learning subscriber, you can either:
Subscribe to JN Learning for one year
Buy this activity
jn-learning_Modal_Multimedia_LoginSubscribe_Purchase
Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close

Name Your Search

Save Search
Close
With a personal account, you can:
  • Track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
jn-learning_Modal_SaveSearch_NoAccess_Purchase
Close

Lookup An Activity

or

Close

My Saved Searches

You currently have no searches saved.

Close
With a personal account, you can:
  • Access free activities and track your credits
  • Personalize content alerts
  • Customize your interests
  • Fully personalize your learning experience
Education Center Collection Sign In Modal Right
Close