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High-quality evidence generated by appropriately powered and controlled trials is needed to advance care for patients with coronavirus disease 2019 (COVID-19) and those who are susceptible to it.1,2 In the midst of the COVID-19 pandemic, multiple similar therapeutic trials are being conducted in parallel, potentially reducing participant accrual across trials. In this systematic review, we characterize the landscape of current COVID-19 trials to better quantify these potential issues.
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Accepted for Publication: June 15, 2020.
Published: July 13, 2020. doi:10.1001/jamanetworkopen.2020.15100
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Kouzy R et al. JAMA Network Open.
Corresponding Authors: Ethan B. Ludmir, MD, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1422, Houston, TX 77030 (email@example.com); Cullen M. Taniguchi, MD, PhD, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1050, Houston, TX 77030 (firstname.lastname@example.org).
Author Contributions: Drs Kouzy and Ludmir had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Kouzy and Abi Jaoude contributed equally as first authors. Drs Taniguchi and Ludmir contributed equally as senior authors.
Concept and design: Kouzy, Abi Jaoude, Taniguchi, Ludmir.
Acquisition, analysis, or interpretation of data: Kouzy, Abi Jaoude, Garcia Garcia, El Alam, Ludmir.
Drafting of the manuscript: Kouzy, Abi Jaoude, Garcia Garcia, Taniguchi, Ludmir.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Kouzy, Abi Jaoude, Garcia Garcia, El Alam, Ludmir.
Obtained funding: Abi Jaoude, Taniguchi.
Administrative, technical, or material support: Abi Jaoude, Taniguchi.
Supervision: Abi Jaoude, Taniguchi, Ludmir.
Conflict of Interest Disclosures: Ms Garcia Garcia reported receiving support from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH) (award number F31DK121384). Dr Taniguchi reported receiving supported from the NIH (award R01CA227517-01A1), Cancer Prevention & Research Institute of Texas (grant RR140012), V Foundation (grant V2015-22), the Kimmel Foundation, Sabin Family Foundation Fellowship, and the McNair Foundation and reported being a member of the clinical advisory board of Accuray outside the submitted work. No other disclosures were reported.
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