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Persistent Symptoms in Patients After Acute COVID-19

Educational Objective
To understand the persistent symptoms in patients after acute COVID-19
1 Credit CME

In Italy, a large proportion of patients with coronavirus disease 2019 (COVID-19) presented with symptoms (71.4% of 31 845 confirmed cases as of June 3, 2020).1 Common symptoms include cough, fever, dyspnea, musculoskeletal symptoms (myalgia, joint pain, fatigue), gastrointestinal symptoms, and anosmia/dysgeusia.24 However, information is lacking on symptoms that persist after recovery. We assessed persistent symptoms in patients who were discharged from the hospital after recovery from COVID-19.

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Article Information

Corresponding Author: Angelo Carfì, MD, Centro Medicina dell’Invecchiamento, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Francesco Vito 1, 00168 Rome, Italy (angelo.carfi@policlinicogemelli.it).

Accepted for Publication: June 23, 2020.

Published Online: July 9, 2020. doi:10.1001/jama.2020.12603

Author Contributions: Drs Carfì and Landi had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Drafting of the manuscript: Carfì, Landi.

Critical revision of the manuscript for important intellectual content: Bernabei, Landi.

Statistical analysis: Carfì.

Supervision: Bernabei, Landi.

Conflict of Interest Disclosures: None reported.

Additional Information: The members of the Gemelli Against COVID-19 Post-Acute Care Study Group are listed in reference 5.

References
1.
Istituto Superiore Sanità. Sorveglianza Integrata COVID-19 in Italia. Published 2020. Accessed June 8, 2020. https://www.epicentro.iss.it/coronavirus/bollettino/Infografica_3giugno%20ITA.pdf
2.
Docherty  AB , Harrison  EM , Green  CA ,  et al; ISARIC4C Investigators.  Features of 20 133 UK patients in hospital with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.   BMJ. 2020;369:m1985. doi:10.1136/bmj.m1985PubMedGoogle ScholarCrossref
3.
Wang  D , Hu  B , Hu  C ,  et al.  Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China.   JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.1585PubMedGoogle ScholarCrossref
4.
Landi  F , Barillaro  C , Bellieni  A ,  et al.  The new challenge of geriatrics: saving frail older people from the SARS-CoV-2 pandemic infection.   J Nutr Health Aging. 2020;24(5):466-470. doi:10.1007/s12603-020-1356-xPubMedGoogle ScholarCrossref
5.
Gemelli Against COVID-19 Post-Acute Care Study Group.  Post-COVID-19 global health strategies: the need for an interdisciplinary approach.   Aging Clin Exp Res. Published online June 11, 2020. doi:10.1007/s40520-020-01616-xPubMedGoogle Scholar
6.
Metlay  JP , Fine  MJ , Schulz  R ,  et al.  Measuring symptomatic and functional recovery in patients with community-acquired pneumonia.   J Gen Intern Med. 1997;12(7):423-430. doi:10.1046/j.1525-1497.1997.00074.xPubMedGoogle ScholarCrossref
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