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Critical Care Medicine

Persistent Symptoms in Patients After Acute COVID-19

Educational Objective
To understand the persistent symptoms in patients after acute COVID-19

1 Credit CME

JAMA

Published Online: July 9, 2020

Research Letter

Article Information and Disclosures

Angelo Carfì, MD¹;

Roberto Bernabei, MD¹;

Francesco Landi, MD, PhD¹;

for the Gemelli Against COVID-19 Post-Acute Care Study Group

Author Affiliations

¹Geriatrics Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

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In Italy, a large proportion of patients with coronavirus disease 2019 (COVID-19) presented with symptoms (71.4% of 31 845 confirmed cases as of June 3, 2020).¹ Common symptoms include cough, fever, dyspnea, musculoskeletal symptoms (myalgia, joint pain, fatigue), gastrointestinal symptoms, and anosmia/dysgeusia.²^- 4 However, information is lacking on symptoms that persist after recovery. We assessed persistent symptoms in patients who were discharged from the hospital after recovery from COVID-19.

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Article Information

Corresponding Author: Angelo Carfì, MD, Centro Medicina dell’Invecchiamento, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Francesco Vito 1, 00168 Rome, Italy (angelo.carfi@policlinicogemelli.it).

Accepted for Publication: June 23, 2020.

Published Online: July 9, 2020. doi:10.1001/jama.2020.12603

Author Contributions: Drs Carfì and Landi had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: All authors.

Drafting of the manuscript: Carfì, Landi.

Critical revision of the manuscript for important intellectual content: Bernabei, Landi.

Statistical analysis: Carfì.

Supervision: Bernabei, Landi.

Conflict of Interest Disclosures: None reported.

Additional Information: The members of the Gemelli Against COVID-19 Post-Acute Care Study Group are listed in reference 5.

References

Istituto Superiore Sanità. Sorveglianza Integrata COVID-19 in Italia. Published 2020. Accessed June 8, 2020. https://www.epicentro.iss.it/coronavirus/bollettino/Infografica_3giugno%20ITA.pdf

Docherty AB , Harrison EM , Green CA , et al; ISARIC4C Investigators. Features of 20 133 UK patients in hospital with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020;369:m1985. doi:10.1136/bmj.m1985 PubMed Google Scholar Crossref

Wang D , Hu B , Hu C , et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(13):1239-1242. doi:10.1001/jama.2020.1585 PubMed Google Scholar Crossref

Landi F , Barillaro C , Bellieni A , et al. The new challenge of geriatrics: saving frail older people from the SARS-CoV-2 pandemic infection. J Nutr Health Aging. 2020;24(5):466-470. doi:10.1007/s12603-020-1356-x PubMed Google Scholar Crossref

Gemelli Against COVID-19 Post-Acute Care Study Group. Post-COVID-19 global health strategies: the need for an interdisciplinary approach. Aging Clin Exp Res. Published online June 11, 2020. doi:10.1007/s40520-020-01616-x PubMed Google Scholar

Metlay JP , Fine MJ , Schulz R , et al. Measuring symptomatic and functional recovery in patients with community-acquired pneumonia. J Gen Intern Med. 1997;12(7):423-430. doi:10.1046/j.1525-1497.1997.00074.x PubMed Google Scholar Crossref

AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.