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Anticoagulation and Antiplatelet Therapy in Atrial FibrillationA Teachable Moment

Educational Objective
To describe current understanding and recommendations for antiplatelet and anticoagulation therapy in patients with atrial fibrillation (AF).
1 Credit CME

A man in his 80s with a history of paroxysmal atrial fibrillation (AF) and transient ischemic attack (TIA) presented to a primary care clinic following a mechanical fall at home.

Two weeks earlier, the patient presented to the emergency department with a large bruise on his left buttock and left elbow after a mechanical fall at home. On discharge, his hemoglobin level was 12.3 g/dL; left hip radiography results showed no evidence of acute fracture or dislocation; and he was ambulatory with a 4-wheel walker. He had had 3 prior falls in the previous year. Although none resulted in fracture, the last 2 falls required hospitalization and discharge to a skilled nursing facility for physical therapy. He was prescribed low-dose aspirin 10 years before, after presenting to the emergency department with transient right-sided weakness and facial droop, and was diagnosed with a TIA. He was subsequently prescribed warfarin after a diagnosis of AF 3 months later and eventually transitioned from warfarin to apixaban at the age of 82 years for ease of use. He had not missed any doses of his apixaban in the past year. His CHA2DS2-VASc score was 5 (2 points for age, 1 point for hypertension, 2 points for TIA history), and he had had no major bleeding episodes.

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CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.

Article Information

Corresponding Author: Justin A. Edward, MD, Internal Medicine Residency Training Program, Department of Medicine, University of Colorado School of Medicine, 12631 East 17th Ave, Mail Stop B178, Aurora, CO 80045 (justin.edward@cuanschutz.edu).

Published Online: July 13, 2020. doi:10.1001/jamainternmed.2020.2495

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References
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Seiffge  DJ , Werring  DJ , Paciaroni  M ,  et al.  Timing of anticoagulation after recent ischaemic stroke in patients with atrial fibrillation.   Lancet Neurol. 2019;18(1):117-126. doi:10.1016/S1474-4422(18)30356-9PubMedGoogle Scholar
2.
January  CT , Wann  LS , Calkins  H ,  et al.  2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in collaboration with the Society of Thoracic Surgeons.   Circulation. 2019;140(2):e125-e151. doi:10.1161/CIR.0000000000000665PubMedGoogle Scholar
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Powers  WJ , Rabinstein  AA , Ackerson  T ,  et al.  Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association.   Stroke. 2019;50(12):e344-e418. doi:10.1161/STR.0000000000000211PubMedGoogle Scholar
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Steinberg  BA , Kim  S , Piccini  JP ,  et al; ORBIT-AF Investigators and Patients.  Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry.   Circulation. 2013;128(7):721-728. doi:10.1161/CIRCULATIONAHA.113.002927PubMedGoogle Scholar
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Lip  GYH , Banerjee  A , Boriani  G ,  et al.  Antithrombotic therapy for atrial fibrillation: CHEST Guideline and expert panel report.   Chest. 2018;154(5):1121-1201. doi:10.1016/j.chest.2018.07.040PubMedGoogle Scholar
AMA CME Accreditation Information

Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00  AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:

  • 1.00 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program;;
  • 1.00 Self-Assessment points in the American Board of Otolaryngology – Head and Neck Surgery’s (ABOHNS) Continuing Certification program;
  • 1.00 MOC points in the American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program;
  • 1.00 Lifelong Learning points in the American Board of Pathology’s (ABPath) Continuing Certification program; and
  • 1.00 CME points in the American Board of Surgery’s (ABS) Continuing Certification program

It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.

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