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The impact of lockdowns implemented in response to coronavirus disease 2019 (COVID-19) on mental health has raised concerns.1,2 Understanding the mechanisms underlying this impact to mitigate it is a research priority.3 We hypothesized that one mechanism involves impaired mood homeostasis (ie, failure to stabilize mood via mood-modifying activities).4
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Accepted for Publication: June 10, 2020.
Corresponding Author: Guy M. Goodwin, MD, Warneford Hospital, Warneford Lane, Oxford OX3 7JX, United Kingdom (firstname.lastname@example.org).
Published Online: July 29, 2020. doi:10.1001/jamapsychiatry.2020.2389
Author Contributions: Dr Taquet had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Taquet.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Taquet.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Taquet, Quoidbach.
Administrative, technical, or material support: Taquet, Fried.
Study supervision: Fried.
Conflict of Interest Disclosures: Dr Goodwin is a National Institute for Health Research Emeritus Senior Investigator; is Medical Director at P1vital Products and holds shares in P1vital and P1vital Products; and has received personal fees from Compass Pathways, Eva Pharma, Merck Sharp & Dohme, Janssen Pharmaceuticals, Lundbeck, Medscape, P1vital, Sage, and Servier. No other disclosures were reported.
Disclaimer: The views expressed are those of the authors and not necessarily those of the UK National Health Service, the National Institute for Health Research, or the Department of Health.
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