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Stroke Thrombolysis With Tenecteplase to Reduce Emergency Department Spread of Coronavirus Disease 2019 and Shortages of Alteplase

Educational Objective
To understand how to limit the risks of the spread of COVID-19 during an acute stroke emergency
1 Credit CME

Measures to reduce emergency department staff exposure to the severe acute respiratory syndrome coronavirus 2 have focused on screening and use of personal protective equipment. Reducing the time and intensity of interactions with individuals with known or suspected cases of coronavirus disease 2019 (COVID-19) is also desirable, insofar as such reductions do not compromise the quality or outcomes of care. The situation of an acute stroke emergency is a particularly vulnerable situation for exposure and transmission, since a substantial proportion of patients are unable to provide a history to screen them out for COVID-19.

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Article Information

Corresponding Author: Steven J. Warach, MD, PhD, Department of Neurology, Dell Medical School, University of Texas at Austin, 1601 Trinity St, Room 10.542, Austin, TX 78712 (steven.warach@austin.utexas.edu).

Published Online: July 20, 2020. doi:10.1001/jamaneurol.2020.2396

Conflict of Interest Disclosures: Dr Warach chairs the independent Data Monitoring Committee for the Phase III, Prospective, Double-blind, Randomized, Placebo-controlled Trial of Thrombolysis in Imaging-Eligible, Late-Window Patients to Assess the Efficacy and Safety of Tenecteplase (TIMELESS) clinical trial of tenecteplase for acute ischemic stroke, for which he receives financial compensation from Genentech. Dr Saver reported grants and personal fees from Boehringer Ingelheim outside the submitted work.

References
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