Corresponding Author: Salman Razvi, MD, Translational and Clinical Research Institute, Newcastle University, Gateshead Health NHS Foundation Trust, Newcastle upon Tyne NE1 3BZ, United Kingdom (salman.razvi@ncl.ac.uk).
Accepted for Publication: May 15, 2020.
Author Contributions: Dr Razvi had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Junejo, Pearce, Zaman, Razvi.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Jabbar, Hollingsworth, Razvi.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Jabbar, Stocken, Razvi.
Obtained funding: Pearce, Razvi.
Administrative, technical, or material support: Ingoe, Junejo, Parikh, Austin, Hollingsworth, Pearce, Greenwood, Zaman.
Supervision: Jabbar, Junejo, Carey, Parikh, Hollingsworth, Stocken, Pearce, Greenwood, Zaman, Razvi.
Conflict of Interest Disclosures: Dr Austin reported receiving personal fees from Abbott Vascular and AstraZeneca and grants from TA Sciences outside the submitted work. Dr Hollingsworth reported receiving a Medical Research Council New Investigator Research Grant (G1100160, 2012-2015) during the conduct of the study. Dr Pearce reported receiving personal fees from Quidel, Sanofi, and Berlin Chemie and nonfinancial support from Apitope BV outside the submitted work. Dr Razvi reported receiving grants from the National Institute for Health Research (NIHR) and nonfinancial support from Amdipharm Pharmaceuticals UK Ltd during the conduct of the study and personal fees from Merck Plc and Abbott Pharmaceuticals Pvt Ltd outside the submitted work. No other disclosures were reported.
Funding/Support: Dr Razvi was funded by an NIHR Career Development Fellowship (CDF-2012-05-231). The research was supported in part by the NIHR infrastructure at the University of Leeds.
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The views expressed in this publication are those of the author(s) and not necessarily those of the National Health Service, the NIHR, or the Department of Health and Social Care. Levothyroxine was provided free of cost by Amdipharm Pharmaceuticals UK Ltd.
Data Sharing Statement: See Supplement 4.
Additional Contributions: Independent trial steering committee: Janis Hickey (chair), Akheel Syed (independent member). Independent data and safety monitoring committee: Colin Dayan (chair), Steff Lewis (statistician), Rajiv Das (magnetic resonance [MR] expert). Tim Hodgson, MClinSci (senior research radiographer), Louise Ward, DCR(R) (radiographer), Dorothy Wallace, MClinSci (radiographer) (Newcastle MR Centre, Newcastle University); Petra Bijsterveld, MA (senior research nurse and MR manager) (University of Leeds); Thomas Chadwick, PhD (clinical trials statistician) (Population Health Sciences Institute, Newcastle University); James Wason, PhD (professor of biostatistics) (Newcastle University); Yan Hunter Blair (Newcastle Pharmacy Production Unit, Newcastle upon Tyne Hospitals); and Ruth Wood (randomization software) and Lee Munro, BSc (trial manager) (Newcastle Clinical Trials Unit, Newcastle University). None of the individuals named above received compensation for their role in the study.
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