Accepted for Publication: June 29, 2020.
Published: July 22, 2020. doi:10.1001/jamanetworkopen.2020.16382
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 McCulloch DJ et al. JAMA Network Open.
Corresponding Author: Denise J. McCulloch, MD, MPH, UW Medicine, 750 Republican St, Chu Lab Room E630, Box 358061, Seattle WA 98109 (firstname.lastname@example.org).
Author Contributions: Dr McCulloch had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: McCulloch, Kim, Englund, Chu.
Acquisition, analysis, or interpretation of data: McCulloch, Wilcox, Logue, Greninger, Englund.
Drafting of the manuscript: McCulloch, Wilcox, Englund, Chu.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: McCulloch, Wilcox.
Obtained funding: Englund, Chu.
Administrative, technical, or material support: Kim, Logue, Greninger, Englund.
Supervision: Logue, Greninger, Chu.
Conflict of Interest Disclosures: Dr Chu reported consulting with GlaxoSmithKline and Merck and receiving research funding from Sanofi Pasteur, Cepheid, and Ellume outside of the submitted work. Dr Greninger reported receiving personal fees from Abbott Molecular outside of the submitted work. Dr Englund reported consulting with Sanofi Pasteur and Meissa Vaccines outside the submitted work. No other disclosures were reported.
Funding/Support: This work was supported by Gates Ventures.
Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Caitlin Wolf, BS, and Gregory Pepper, BS (both of University of Washington, Seattle), assisted with acquisition of data. Jay Shendure, MD, PhD (University of Washington, Seattle; Brotman Baty Institute, Seattle; and Howard Hughes Medical Institute, Chevy Chase, Maryland), assisted with concept and design, obtaining funding, and critical revision of the manuscript. James P. Hughes, PhD (Fred Hutchinson Cancer Research Center, Seattle, and University of Washington, Seattle), assisted with statistical analysis and critical revision of the manuscript. Michael J. Boeckh, MD, PhD (University of Washington, Seattle; Brotman Baty Institute, Seattle; and Fred Hutchinson Cancer Research Center, Seattle), Keith R. Jerome, MD, PhD (University of Washington, Seattle, and Fred Hutchinson Cancer Research Center, Seattle), and Michael Jackson, PhD (Kaiser Permanente Washington Health Research Institute, Seattle), assisted with critical revision of the manuscript. We also acknowledge the University of Washington medical students who volunteered to help with this study. None of these individuals received financial compensation for their contributions to the study.
CP , Tran
LTT , Cowling
BJ , Sullivan
SG . Self-collected compared with professional-collected swabbing in the diagnosis of influenza in symptomatic individuals: a meta-analysis and assessment of validity. J Clin Virol
. 2019;118:28-35. doi:10.1016/j.jcv.2019.07.010
Z , Zhuang
H , Zhao
C , Dong
Q , Peng
G , Dwyer
DE . Using patient-collected clinical samples and sera to detect and quantify the severe acute respiratory syndrome coronavirus (SARS-CoV). Virol J
. 2007;4:32. doi:10.1186/1743-422X-4-32
P , Paton
RS , Ghafari
M , Lourenco
J . Estimating false-negative detection rate of SARS-CoV-2 by RT-PCR. medRxiv. Preprint posted online April 14, 2020. doi:10.1101/2020.04.05.20053355
HY , Englund
JA , Starita
et al; Seattle Flu Study Investigators. Early Detection of Covid-19 through a Citywide Pandemic Surveillance Platform. N Engl J Med
. 2020. doi:10.1056/NEJMc2008646