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Recent reports in several medical journals, including JAMA, and the general media have highlighted the emergence of coronavirus disease 2019 (COVID-19)–associated inflammatory syndromes in children.1- 3 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to induce this new condition, which has been called pediatric multisystem inflammatory syndrome (PIMS) or pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS) and described in detail by investigators in Europe and New York, New York.1- 4 Additionally, investigators in Italy have reported5 a dramatic surge in Kawasaki disease (KD), often associated with positive serological test results for COVID-19. As of May 31, 2020, the New York State Department of Health is investigating 188 reported hospitalized cases and 3 deaths of children, predominantly school-aged, who experienced symptoms similar to KD and toxic shock–like syndrome that were possibly linked to COVID-19.6 Similarly, more than 200 cases have been reported to the European Centre for Disease Prevention and Control. The US Centers for Disease Control and Prevention has also issued a statement and case reports for the emerging condition, now also termed multisystem inflammatory syndrome of childhood (MIS-C), which is currently under investigation.7 Simultaneously, sporadic cases of MIS-C, KD, and/or Kawasaki shock syndrome have appeared in public health reports and the media, particularly in Washington and other West Coast states.
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Corresponding Author: Michael A. Portman, MD, Seattle Children’s Research Institute, University of Washington, 1900 9th Ave, Seattle WA 98101 (firstname.lastname@example.org).
Published Online: July 20, 2020. doi:10.1001/jamapediatrics.2020.2810
Conflict of Interest Disclosures: None reported.
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