The reach of the coronavirus disease 2019 (COVID-19) pandemic is global, a health crisis with a ubiquity never before experienced. While the physical health consequences of COVID-19 appear to affect proportionally fewer children compared with adults, its psychosocial consequences may be magnified within families who consistently weather a landscape of severe stressors or adverse childhood experiences (ACEs; eg, domestic violence, abuse, maltreatment, and parent mental health issues). Leveraging the scientific evidence of early childhood research can aid in developing and implementing evidence-based practices that reduce risk and promote resilience within vulnerable families.