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Incidental Thyroid Mass in a Patient With Oropharyngeal Squamous Cell Carcinoma

Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.
1 Credit CME

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Article Information

Corresponding Author: Kinneri Mehta, MD, Division of Otolaryngology–Head and Neck Surgery, University of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030 (mehtakinneri@gmail.com).

Published Online: July 30, 2020. doi:10.1001/jamaoto.2020.1616

Conflict of Interest Disclosures: None reported.

Additional Contributions: We thank the patient for granting permission to publish this information.

References
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Vatsyayan  A , Mandlik  D , Patel  P ,  et al.  Metastasis of squamous cell carcinoma of the head and neck to the thyroid: a single institution’s experience with a review of relevant publications.   Br J Oral Maxillofac Surg. 2019;57(7):609-615. doi:10.1016/j.bjoms.2019.05.012PubMedGoogle ScholarCrossref
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Jalaludin  MA , Rajadurai  P , Va  R , Prasad  U .  Thyroid metastasis from nasopharyngeal carcinoma: a case report.   J Laryngol Otol. 1994;108(10):886-888. doi:10.1017/S0022215100128415PubMedGoogle ScholarCrossref
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Aparici  CM , Win  AZ .  Two cases of thyroid metastasis from head and neck squamous cell carcinoma detected by FDG-PET/CT.   J Clin Imaging Sci. 2014;4:62.PubMedGoogle ScholarCrossref
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Takenobu  M , Moritani  S , Yoshioka  K , Morisaki  T , Kitano  H .  A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma.   Endocr J. 2018;65(4):479-483. doi:10.1507/endocrj.EJ17-0553PubMedGoogle ScholarCrossref
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Chen  YK , Chen  YL , Cheng  RH , Yeh  CL , Lee  CC , Hsu  CH .  The significance of FDG uptake in bilateral thyroid glands.   Nucl Med Commun. 2007;28(2):117-122. doi:10.1097/MNM.0b013e328013eaf7PubMedGoogle ScholarCrossref
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Affandi  KA , Tizen  NMS , Mustangin  M , Zin  RRMRM .  p40 Immunohistochemistry is an excellent marker in primary lung squamous cell carcinoma.   J Pathol Transl Med. 2018;52(5):283-289. doi:10.4132/jptm.2018.08.14PubMedGoogle ScholarCrossref
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Suzuki  A , Hirokawa  M , Takada  N ,  et al.  Diagnostic significance of PAX8 in thyroid squamous cell carcinoma.   Endocr J. 2015;62(11):991-995. doi:10.1507/endocrj.EJ15-0226PubMedGoogle ScholarCrossref
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Jankowska  P , Teoh  EM , Fisher  C , Rhys Evans  P , Nutting  CM , Harrington  KJ .  Case report: isolated intrathyroid metastasis from undifferentiated and squamous carcinoma of the head and neck: the case for surgery and re-irradiation.   Br J Radiol. 2008;81(966):e154-e161. doi:10.1259/bjr/26919796PubMedGoogle ScholarCrossref
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Gillison  ML , Trotti  AM , Harris  J ,  et al.  Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial.   Lancet. 2019;393(10166):40-50. doi:10.1016/S0140-6736(18)32779-XPubMedGoogle ScholarCrossref
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