Accepted for Publication: July 6, 2020.
Published Online: July 27, 2020. doi:10.1001/jamacardio.2020.3557
Correction: This article was corrected on August 25, 2020, to fix pervasive errors in statistical numbers and data in the Abstract, Methods and Results sections, Tables, and Figures 1 and 2.
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Puntmann VO et al. JAMA Cardiology.
Corresponding Author: Eike Nagel, MD, Institute for Experimental and Translational Cardiovascular Imaging, DZHK Centre for Cardiovascular Imaging, University Hospital Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main 60590, Germany (eike.nagel@cardiac-imaging.org).
Author Contributions: Drs Puntmann and Nagel had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Puntmann, Shchendrygina, Vasa-Nicotera, Zeiher, Nagel.
Acquisition, analysis, or interpretation of data: Puntmann, Carerj, Wieters, Fahim, Arendt, Hoffmann, Escher, Vehreschild, Nagel.
Drafting of the manuscript: Puntmann, Shchendrygina, Nagel.
Critical revision of the manuscript for important intellectual content: Puntmann, Carerj, Wieters, Fahim, Arendt, Hoffmann, Escher, Vasa-Nicotera, Zeiher, Vehreschild, Nagel.
Statistical analysis: Puntmann, Nagel.
Obtained funding: Puntmann, Zeiher, Nagel.
Administrative, technical, or material support: Puntmann, Carerj, Wieters, Fahim, Arendt, Escher, Vehreschild, Nagel.
Study supervision: Puntmann, Wieters, Arendt, Vasa-Nicotera, Vehreschild, Nagel.
Conflict of Interest Disclosures: Dr Escher has received personal fees from Institut Kardiale Diagnostik und Therapie outside the submitted work. Dr Zeiher has received grants from the German Centre for Cardiovascular Research during the conduct of the study and personal fees from Sanofi, Amgen, Boehringer Ingelheim, and Novo Nordisk outside the submitted work. Dr Vehreschild has received grants from BioNTech and Takeda outside the submitted work. Dr Nagel has received grants from Bayer, the German Ministry for Education and Research, Deutsche Herzstiftung e.V., Neosoft Technologies, and Cardio-Pulmonary Institute and personal fees from Bayer. No other disclosures were reported.
Funding/Support: Drs Puntmann, Arendt, Escher, Vasa-Nicotera, Zeiher, and Nagel were supported by grants from the German Ministry of Education and Research via the German Centre for Cardiovascular Research (DZHK) partner site RheinMain, Deutsche Herzstiftung e.V., Bayer, and Cardio-Pulmonary Institute
Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We acknowledge the dedicated support of clinical research support staff of the Institute of Experimental and Translational Cardiovascular Imaging, including Tammy Wolf, Thourier Azdad, Franziska Weis, Deniz Desik, BA, and Layla Laghchioua, MSc, as well as of the Department of Infectious Diseases, University Hospital Frankfurt. We are very grateful to our colleagues of the Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Frankfurt am Main, Germany, for treating all critically ill patients with COVID-19. Contributors were not compensated for their work.
6.Chen
L , Li
X , Chen
M , Feng
Y , Xiong
C . The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2.
Cardiovasc Res. 2020;116(6):1097-1100. doi:
10.1093/cvr/cvaa078PubMedGoogle ScholarCrossref 10.Huang
L , Zhao
P , Tang
D ,
et al. Cardiac involvement in recovered COVID-19 patients identified by magnetic resonance imaging.
JACC Cardiovasc Imaging. Published online May 12, 2020. doi:
10.1016/j.jcmg.2020.05.004Google Scholar 13.Harris
PA , Taylor
R , Thielke
R , Payne
J , Gonzalez
N , Conde
JG . Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support.
J Biomed Inform. 2009;42(2):377-381. doi:
10.1016/j.jbi.2008.08.010PubMedGoogle ScholarCrossref 15.Fernández-Jiménez
R , Sánchez-González
J , Agüero
J ,
et al. Fast T2 gradient-spin-echo (T2-GraSE) mapping for myocardial edema quantification: first in vivo validation in a porcine model of ischemia/reperfusion.
J Cardiovasc Magn Reson. 2015;17(1):92. doi:
10.1186/s12968-015-0199-9PubMedGoogle ScholarCrossref 18.Puntmann
VO , Valbuena
S , Hinojar
R ,
et al; SCMR Clinical Trial Writing Group. Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research: part I—analytical validation and clinical qualification.
J Cardiovasc Magn Reson. 2018;20(1):67. doi:
10.1186/s12968-018-0484-5PubMedGoogle ScholarCrossref 20.Schulz-Menger
J , Bluemke
DA , Bremerich
J ,
et al. Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing.
J Cardiovasc Magn Reson. 2013;15(1):35. doi:
10.1186/1532-429X-15-35PubMedGoogle ScholarCrossref 21.Dabir
D , Child
N , Kalra
A ,
et al. Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study.
J Cardiovasc Magn Reson. 2014;16(1):69. doi:
10.1186/s12968-014-0069-xPubMedGoogle ScholarCrossref 23.Puntmann
VO , Carr-White
G , Jabbour
A ,
et al; International T1 Multicentre CMR Outcome Study. Native T1 and ECV of noninfarcted myocardium and outcome in patients with coronary artery disease.
J Am Coll Cardiol. 2018;71(7):766-778. doi:
10.1016/j.jacc.2017.12.020PubMedGoogle ScholarCrossref 24.Puntmann
VO , Carr-White
G , Jabbour
A ,
et al; International T1 Multicentre CMR Outcome Study. T1-mapping and outcome in nonischemic cardiomyopathy: all-cause mortality and heart failure.
JACC Cardiovasc Imaging. 2016;9(1):40-50. doi:
10.1016/j.jcmg.2015.12.001PubMedGoogle ScholarCrossref 25.Gravinay
P , Issa
N , Girard
D , Camou
F , Cochet
H . CMR and serology to diagnose COVID-19 infection with primary cardiac involvement.
Eur Heart J Cardiovasc Imaging. Published online June 17, 2020. doi:
10.1093/ehjci/jeaa169PubMedGoogle Scholar 26.Luetkens
JA , Isaak
A , Zimmer
S ,
et al. Diffuse myocardial inflammation in COVID-19 associated myocarditis detected by multiparametric cardiac magnetic resonance imaging.
Circ Cardiovasc Imaging. 2020;13(5):e010897. doi:
10.1161/CIRCIMAGING.120.010897PubMedGoogle Scholar 27.Caforio
ALP , Pankuweit
S , Arbustini
E ,
et al; European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases.
Eur Heart J. 2013;34(33):2636-2648. doi:
10.1093/eurheartj/eht210PubMedGoogle ScholarCrossref