In the midst of the deadliest pandemic since 1918, the question of how to reopen colleges safely after months of lockdown is of great concern. First and foremost, the strategy cannot be a one-size-fits-all approach. Rather, the best-prepared colleges will use a multifaceted approach that leverages a range of public health strategies best suited to each institution’s resources, location, and culture. Containing coronavirus disease 2019 (COVID-19) requires testing; behavioral interventions to reduce the reproductive number (Rt), such as social distancing, masking, and contact tracing; and limiting the influx of new infections from outside campus.