Quiz

Surgery

Association of Nonoperative Management Using Antibiotic Therapy vs Laparoscopic Appendectomy With Treatment Success and Disability Days in Children With Uncomplicated Appendicitis

Educational Objective
To understand differences in outcomes of appendicitis when the treatment approach is chosen by patients and their families.

1 Credit CME

JAMA

August 11, 2020

Original Investigation

Article Information and Disclosures

Author Affiliations

¹Center for Surgical Outcomes Research, Abigail Wexner Research Institute at Nationwide Children’s Hospital, The Ohio State University College of Medicine, Columbus, Ohio
²Department of Pediatric Surgery, Nationwide Children’s Hospital, Columbus, Ohio
³Departments of Biomedical Informatics and Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, Ohio
⁴Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri
⁵Section of Pediatric Surgery, Department of Surgery, University of Chicago Medicine and Biologic Sciences, Chicago, Illinois
⁶Division of Pediatric Surgery, Department of Surgery, University of Michigan School of Medicine, Ann Arbor
⁷Division of Pediatric Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio
⁸Division of Pediatric Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
⁹Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee
¹⁰Division of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis
¹¹Division of Pediatric Surgery, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois
¹²Division of Pediatric Surgery, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky

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Original Investigation

Antibiotics vs Appendectomy for Uncomplicated Appendicitis Treatment

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Patient Choice in Management of Pediatric Appendicitis

Peter C. Minneci, MD, MHSc; Justin B. Mahida, MD, MBA; Daniel L. Lodwick, MD, MS; Jason P. Sulkowski, MD; Kristine M. Nacion, MPH; Jennifer N. Cooper, PhD, MS; Erica J. Ambeba, PhD, MPH; R. Lawrence Moss, MD; Katherine J. Deans, MD, MHSc
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Antibiotic Therapy vs Appendectomy for Acute Uncomplicated Appendicitis

Libin Huang, MD; Yuan Yin, MD; Lie Yang, MD, PhD; Cun Wang, MD, PhD; Yuan Li, MD, PhD; Zongguang Zhou, MD, PhD
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Time to Appendectomy and Adverse Outcomes in Children

Stephanie K. Serres, MD, PhD; Danielle B. Cameron, MD, MPH; Charity C. Glass, MD, MPP; Dionne A. Graham, PhD; David Zurakowski, PhD; Mahima Karki, BA; Seema P. Anandalwar, MD; Shawn J. Rangel, MD, MSCE
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Preference for Surgery or Antibiotics for Treatment of Appendicitis

Alexis L. Hanson, BA; Ross D. Crosby, PhD; Marc D. Basson, MD, PhD, MBA
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Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis

Paulina Salminen, MD, PhD; Risto Tuominen, MPH, PhD; Hannu Paajanen, MD, PhD; Tero Rautio, MD, PhD; Pia Nordström, MD, PhD; Markku Aarnio, MD, PhD; Tuomo Rantanen, MD, PhD; Saija Hurme, MSc; Jukka-Pekka Mecklin, MD, PhD; Juhani Sand, MD, PhD; Johanna Virtanen, MD, PhD; Airi Jartti, MD, PhD; Juha M. Grönroos, MD, PhD
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Nonoperative Management of Noncomplicated Appendicitis

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Quality of Life and Patient Satisfaction After Antibiotic Therapy vs Appendectomy

Suvi Sippola, MD; Jussi Haijanen, MD; Lauri Viinikainen, BM; Juha Grönroos, MD, PhD; Hannu Paajanen, MD, PhD; Tero Rautio, MD, PhD; Pia Nordström, MD, PhD; Markku Aarnio, MD, PhD; Tuomo Rantanen, MD, PhD; Saija Hurme, MSc; Jukka-Pekka Mecklin, MD, PhD; Juhani Sand, MD, PhD; Airi Jartti, MD, PhD; Paulina Salminen, MD, PhD
Clinical Trials Update

Antibiotics on Par With Surgery for Appendicitis

Anita Slomski, MA
Original Investigation

Oral Moxifloxacin vs Intravenous Ertapenem and Oral Levofloxacin for Uncomplicated Appendicitis

Suvi Sippola, MD; Jussi Haijanen, MD; Juha Grönroos, MD, PhD; Tero Rautio, MD, PhD; Pia Nordström, MD, PhD; Tuomo Rantanen, MD, PhD; Tarja Pinta, MD, PhD; Imre Ilves, MD, PhD; Anne Mattila, MD, PhD; Jukka Rintala, MD, PhD; Eliisa Löyttyniemi, MSc; Saija Hurme, MSc; Ville Tammilehto, MD; Harri Marttila, MD, PhD; Sanna Meriläinen, MD, PhD; Johanna Laukkarinen, MD, PhD; Eeva-Liisa Sävelä, MD; Heini Savolainen, MD, PhD; Tomi Sippola, MD; Markku Aarnio, MD, PhD; Hannu Paajanen, MD, PhD; Paulina Salminen, MD, PhD
Research Letter

Initial Treatment With Antibiotics vs Surgery and Treatment Success and Disability in Children With Appendicitis

Peter C. Minneci, MD, MHSc; Erinn M. Hade, PhD; Gregory A. Metzger, MD; Jacqueline M. Saito, MD; Grace Z. Mak, MD; Katherine J. Deans, MD, MHSc; Midwest Pediatric Surgery Consortium; Ronald B. Hirschl; Samir Gadepalli; Michael A. Helmrath; Charles M. Leys; Thomas T. Sato; Dave R. Lal; Matthew P. Landman; Rashmi Kabre; Mary E. Fallat; Jennifer N. Cooper

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Key Points

Question Among children with uncomplicated appendicitis, what is the success rate of an initial nonoperative management strategy with antibiotic therapy alone and is this approach associated with fewer disability days compared with an initial strategy of urgent laparoscopic surgery?

Findings In this nonrandomized controlled intervention study that used propensity score weighting and included 1068 children, 67.1% of the children who received initial nonoperative management with antibiotics alone did not require appendectomy by 1 year. Compared with a strategy of urgent surgery (≤12 hours of admission), initial management with antibiotics alone was significantly associated with fewer patient disability days at 1 year (6.6 days vs 10.9 days).

Meaning Among children with uncomplicated appendicitis, an initial nonoperative management strategy with antibiotics was successful for most children and, compared with urgent surgery, was associated with significantly fewer disability days at 1 year. However, the prespecified thresholds for success rate of nonoperative management and disability days were not met, and there were substantial missing data.

Abstract

Importance Nonoperative management with antibiotics alone has the potential to treat uncomplicated pediatric appendicitis with fewer disability days than surgery.

Objective To determine the success rate of nonoperative management and compare differences in treatment-related disability, satisfaction, health-related quality of life, and complications between nonoperative management and surgery in children with uncomplicated appendicitis.

Design, Setting, and Participants Multi-institutional nonrandomized controlled intervention study of 1068 children aged 7 through 17 years with uncomplicated appendicitis treated at 10 tertiary children’s hospitals across 7 US states between May 2015 and October 2018 with 1-year follow-up through October 2019. Of the 1209 eligible patients approached, 1068 enrolled in the study.

Interventions Patient and family selection of nonoperative management with antibiotics alone (nonoperative group, n = 370) or urgent (≤12 hours of admission) laparoscopic appendectomy (surgery group, n = 698).

Main Outcomes and Measures The 2 primary outcomes assessed at 1 year were disability days, defined as the total number of days the child was not able to participate in all of his/her normal activities secondary to appendicitis-related care (expected difference, 5 days), and success rate of nonoperative management, defined as the proportion of patients initially managed nonoperatively who did not undergo appendectomy by 1 year (lowest acceptable success rate, ≥70%). Inverse probability of treatment weighting (IPTW) was used to adjust for differences between treatment groups for all outcome assessments.

Results Among 1068 patients who were enrolled (median age, 12.4 years; 38% girls), 370 (35%) chose nonoperative management and 698 (65%) chose surgery. A total of 806 (75%) had complete follow-up: 284 (77%) in the nonoperative group; 522 (75%) in the surgery group. Patients in the nonoperative group were more often younger (median age, 12.3 years vs 12.5 years), Black (9.6% vs 4.9%) or other race (14.6% vs 8.7%), had caregivers with a bachelor’s degree (29.8% vs 23.5%), and underwent diagnostic ultrasound (79.7% vs 74.5%). After IPTW, the success rate of nonoperative management at 1 year was 67.1% (96% CI, 61.5%-72.31%; P = .86). Nonoperative management was associated with significantly fewer patient disability days at 1 year than did surgery (adjusted mean, 6.6 vs 10.9 days; mean difference, −4.3 days (99% CI, −6.17 to −2.43; P < .001). Of 16 other prespecified secondary end points, 10 showed no significant difference.

Conclusion and Relevance Among children with uncomplicated appendicitis, an initial nonoperative management strategy with antibiotics alone had a success rate of 67.1% and, compared with urgent surgery, was associated with statistically significantly fewer disability days at 1 year. However, there was substantial loss to follow-up, the comparison with the prespecified threshold for an acceptable success rate of nonoperative management was not statistically significant, and the hypothesized difference in disability days was not met.

Trial Registration ClinicalTrials.gov Identifier: NCT02271932

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Article Information

Corresponding Author: Peter C. Minneci, MD, MHSc, Center for Surgical Outcomes Research, Abigail Wexner Research Institute at Nationwide Children’s Hospital, 700 Children’s Dr, FB 3A.3, Columbus, OH 43205 (peter.minneci@nationwidechildrens.org).

Accepted for Publication: June 3, 2020.

Published Online: July 27, 2020. doi:10.1001/jama.2020.10888

Author Contributions: Dr Minneci had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Concept and design: Minneci, Hade, Saito, Gadepalli, Kohler, Sato, Lal, Kabre, Fallat, Cooper, Deans.

Acquisition, analysis, or interpretation of data: Minneci, Hade, Lawrence, Sebastião, Saito, Mak, Hirschl, Gadepalli, Helmrath, Kohler, Leys, Sato, Lal, Landman, Kabre, Fallat, Cooper.

Drafting of the manuscript: Minneci, Hade, Lal, Deans.

Critical revision of the manuscript for important intellectual content: Minneci, Hade, Lawrence, Sebastião, Saito, Mak, Hirschl, Gadepalli, Helmrath, Kohler, Leys, Sato, Lal, Landman, Kabre, Fallat, Cooper, Deans.

Statistical analysis: Hade, Sebastião, Gadepalli, Cooper.

Obtained funding: Minneci, Deans.

Administrative, technical, or material support: Minneci, Hade, Lawrence, Sebastião, Hirschl, Gadepalli, Helmrath, Kohler, Sato, Lal, Kabre.

Supervision: Minneci, Hade, Hirschl, Helmrath, Sato, Lal, Landman, Kabre, Cooper, Deans.

Other - site principal investigator: Saito.

Conflict of Interest Disclosures: Dr Minneci reported grants from PCORI during the conduct of the study. Dr Hade reported grants from PCORI during the conduct of the study; grants from NIH, grants from Smart Columbus, and grants from PCORI/PCORnet outside the submitted work. Dr Saito reported grants from PCORI during the conduct of the study; grants from AHRQ outside the submitted work. Dr Mak reported grants from PCORI during the conduct of the study; grants from Thrasher outside the submitted work. Dr Gadepalli reported grants from PCORI during the conduct of the study. Dr Sato reported grants from PCORI during the conduct of the study. Dr Cooper reported grants from PCORI during the conduct of the study. Dr Deans reported grants from PCORI during the conduct of the study. No other disclosures were reported.

Funding/Support: This study is funded by award CER-1507-31325 from PCORI, an independent, nonprofit organization authorized by the US Congress in 2010. This project is also supported by grant UL1TR001070 from the National Center for Advancing Translational Sciences.

Role of the Funder/Sponsor: Funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Group Information: Gail Besner, MD, Nationwide Children’s Hospital; Jessica Kandel, MD, University of Chicago Medicine–Comer Children’s Hospital; Frederick Rescorla, MD, Riley Children’s Hospital; Marleta Reynolds, MD; Ann & Robert Lurie Children’s Hospital of Chicago; Daniel von Allmen, MD, Cincinnati Children’s Hospital and Medical Center; and Brad Warner, MD, St Louis Children’s Hospital; Cynthia Downard, MD, University of Louisville School of Medicine; Beth Rymeski, MD, Cincinnati Children’s Hospital and Medical Center; Julia Grabowksi, MD, Ann & Robert Lurie Children’s Hospital of Chicago; Peter C. Minneci, MD, MHSc, Nationwide Children’s Hospital, Columbus, Ohio; Jacqueline M. Saito, MD, Washington University School of Medicine, St Louis, Missouri; Grace Z. Mak, MD, University of Chicago; Ronald B. Hirschl, MD, University of Michigan, Ann Arbor; Samir Gadepalli, MD, MBA, University of Michigan, Ann Arbor; Michael A. Helmrath, MD, University of Cincinnati College of Medicine; Jonathan E. Kohler, MD, University of Wisconsin, Madison; Charles M. Leys, MD, University of Wisconsin, Madison; Thomas T. Sato, MD, Medical College of Wisconsin, Milwaukee; Dave R. Lal, MD, Medical College of Wisconsin, Milwaukee; Matthew P. Landman, MD, Indiana University School of Medicine, Indianapolis; Rashmi Kabre, MD, Northwestern University Feinberg School of Medicine, Chicago; Mary E. Fallat, MD, University of Louisville School of Medicine, Louisville, Kentucky; and Katherine J. Deans, MD, MHSc, Nationwide Children’s Hospital, Columbus. None were compensated for their role in the study.

Disclaimer: The content of this work is solely the responsibility of the authors and does not necessarily represent the official views of PCORI, its Board of Governors or Methodology Committee, the National Center for Advancing Translational Sciences or the National Institutes of Health.

Additional Contributions: We thank our multidisciplinary stakeholder members for all of their input and dedication to this study: Patient or caregivers: Alyssa Gilman, Amanda Forystek, Endia McHenry, Sonya Sigers, Kaleb Boyd, Liz Sullivan, Maxwell Blom, Melissa R. Blom, Lorelei Moulin, Darcy Moulin, Nicholas Hawke, Kimberly Hawke, William Hawke, Nicolas Valdes, Lisa Valdes, Maurilio Valdes, Nolan Chehak, LuAnne Farr, Joshua Montalvo, Illuminado Castellano, Rheya Wheeler, Cherie Caldwell, Robert Rohloff, Samantha Schlaeppi, Tanner Goodman, Lisa Shrader, William Blake Godwin, Diana Godwin, Trinity Patten, Rebeccah Abanukam, Aubrey K. Gibson, Aria K. Gibson, Jason Gibson, Christy L. McDonald, and Bobby J. McDonald Jr; Nationwide Children’s Hospital: R. Lawrence Moss, MD, Courtney Porter, RN, Kathryn Nuss, MD, Paul Seese, RN; Sean Gleeson, MD, MBA; University of Chicago Medicine: Alisa McQueen, MD; University of Louisville School of Medicine: Stephan Baum, MD; Ann & Robert Lurie Children’s Hospital of Chicago: Dana Aronson Schinasi, MD; Washington University: Gian Musarra, MD, Medical College of Wisconsin: Michael Levas, MD; and Darryl Robbins, DO, community physician, all of whom received a stipend for their participation. We also thank the following staff members on this project: Beth Fischer, PhD, and Karen Leonhart, BS, Nationwide Children’s Hospital; Jana Creps, University of Michigan–C.S. Mott Children’s Hospital; Michelle Knezevich, MS, Children’s Hospital of Milwaukee, who received no remuneration beyond their salaries.

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Association of Nonoperative Management Using Antibiotic Therapy vs Laparoscopic Appendectomy With Treatment Success and Disability Days in Children With Uncomplicated Appendicitis

Antibiotics vs Appendectomy for Uncomplicated Appendicitis Treatment

Antibiotics vs Surgery for Acute Appendicitis

Patient Choice in Management of Pediatric Appendicitis

Antibiotic Therapy vs Appendectomy for Acute Uncomplicated Appendicitis

Time to Appendectomy and Adverse Outcomes in Children

Preference for Surgery or Antibiotics for Treatment of Appendicitis

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis

Nonoperative Management of Noncomplicated Appendicitis

Quality of Life and Patient Satisfaction After Antibiotic Therapy vs Appendectomy

Nonoperative Treatment of Appendicitis: What Is Success?

Antibiotics on Par With Surgery for Appendicitis

Oral Moxifloxacin vs Intravenous Ertapenem and Oral Levofloxacin for Uncomplicated Appendicitis

Initial Treatment With Antibiotics vs Surgery and Treatment Success and Disability in Children With Appendicitis

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Nonoperative Treatment of Appendicitis: What Is Success?

Antibiotics on Par With Surgery for Appendicitis

Oral Moxifloxacin vs Intravenous Ertapenem and Oral Levofloxacin for Uncomplicated Appendicitis

Initial Treatment With Antibiotics vs Surgery and Treatment Success and Disability in Children With Appendicitis

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Treating Pediatric Appendicitis Nonoperatively

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