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Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19)

Educational Objective
To understand the age-related differences in SARS-CoV-2 in Patients with mild to moderate COVID-19
1 Credit CME

Children are susceptible to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but generally present with mild symptoms compared with adults.1 Children drive spread of respiratory and gastrointestinal illnesses in the population,2 but data on children as sources of SARS-CoV-2 spread are sparse.

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Article Information

Accepted for Publication: May 31, 2020.

Corresponding Author: Taylor Heald-Sargent, MD, PhD, Division of Infectious Diseases, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital, 225 E Chicago Ave, Box 20, Chicago, IL 60611 (thsargent@luriechildrens.org).

Published Online: July 30, 2020. doi:10.1001/jamapediatrics.2020.3651

Author Contributions: Drs Heald-Sargent and Kociolek had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Heald-Sargent, Muller, Kociolek.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Heald-Sargent, Muller, Kociolek.

Critical revision of the manuscript for important intellectual content: All authors.

Statistical analysis: Heald-Sargent, Kociolek.

Administrative, technical, or material support: All authors.

Study supervision: Muller, Patel, Kociolek.

Conflict of Interest Disclosures: Dr Muller has received grants from Ansun BioPharma, Astellas Pharma, AstraZeneca, Abbott Laboratories, Janssen Pharmaceuticals, Karius, Merck, Melinta Therapeutics, Roche, Tetraphase Pharmaceuticals, and Seqirus. Dr Patel has received grants from Aqua Pharmaceuticals. Dr Kociolek has received grants from Merck. No other disclosures were reported.

Funding/Support: Drs Heald-Sargent and Kociolek were supported by grants T32AI095207 and K23AI123525, respectively, from the National Institute of Allergy and Infectious Diseases.

Role of the Funder/Sponsor: The funder had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

References
1.
Lu  X , Zhang  L , Du  H ,  et al; Chinese Pediatric Novel Coronavirus Study Team.  SARS-CoV-2 infection in children.   N Engl J Med. 2020;382(17):1663-1665. doi:10.1056/NEJMc2005073PubMedGoogle ScholarCrossref
2.
Paules  C , Subbarao  K .  Influenza.   Lancet. 2017;390(10095):697-708. doi:10.1016/S0140-6736(17)30129-0PubMedGoogle ScholarCrossref
3.
Cao  Q , Chen  YC , Chen  CL , Chiu  CH .  SARS-CoV-2 infection in children: transmission dynamics and clinical characteristics.   J Formos Med Assoc. 2020;119(3):670-673. doi:10.1016/j.jfma.2020.02.009PubMedGoogle ScholarCrossref
4.
Liu  Y , Yan  LM , Wan  L ,  et al.  Viral dynamics in mild and severe cases of COVID-19.   Lancet Infect Dis. 2020;20(6):656-657. doi:10.1016/S1473-3099(20)30232-2PubMedGoogle ScholarCrossref
5.
L’Huillier  AG , Torriani  G , Pigny  F , Kaiser  L , Eckerle  I .  Culture-competent SARS-CoV-2 in nasopharynx of symptomatic neonates, children, and adolescents.   Emerg Infect Dis. 2020;26(10):26.PubMedGoogle ScholarCrossref
6.
Moreira  LP , Watanabe  ASA , Camargo  CN , Melchior  TB , Granato  C , Bellei  N .  Respiratory syncytial virus evaluation among asymptomatic and symptomatic subjects in a university hospital in Sao Paulo, Brazil, in the period of 2009-2013.   Influenza Other Respir Viruses. 2018;12(3):326-330. doi:10.1111/irv.12518PubMedGoogle ScholarCrossref
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