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A woman in her 70s presented with a week of painless, rapidly progressive, edematous, necrotic papules and plaques on the extremities, buttocks, and face with sharp demarcation at the nasolabial folds and extension into the oral mucosa (Figure, A and B). Notable symptoms included 4 months of extreme fatigue, 20.4 kg weight loss, and a recent episode of hematochezia. Her medical history included diabetes, hyperlipidemia, and hypertension that were well controlled with simvastatin, chlorthalidone, hydralazine hydrochloride, lisinopril, and verapamil hydrochloride. She had been taking these medications for 5 years with no new exposures. Age-appropriate cancer screening was up to date. She was afebrile and hemodynamically stable, but laboratory evaluation revealed that she had leukocytosis, normocytic anemia, elevated erythrocyte sedimentation rate, hematuria, and proteinuria. On hospital day 2, she developed bright red blood per rectum, necessitating transfusion. A computed tomography of the chest, abdomen, and pelvis revealed parenchymal lung nodules. On admission, punch biopsies of the skin were performed for both histological examination and bacterial, fungal, and acid-fast bacterial cultures (Figure, C and D).
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D. Drug-induced vasculitis
On presentation, the symptoms were suggestive of malignant neoplasm–induced or hydralazine-associated Sweet syndrome. In addition to cessation of hydralazine, high-dose corticosteroids were started, which were ineffective over several days but subsequently held after preliminary pathologic findings demonstrated possible fungal forms. Histological examination revealed a neutrophil-rich infiltrate in a predominately perivascular pattern with extravasated erythrocytes, leukocytoclasis with karyorrhectic debris, fibrinoid degeneration of vessels walls, and cryptococcoid forms. Subsequently, the results of microbial stains, including periodic acid–Schiff, Grocott methenamine silver, Gram, and acid-fast bacillus, as well as tissue cultures were unremarkable. Rheumatological workup was notable for positive antinuclear antibody titer (1:160), antineutrophil cytoplasmic antibody (ANCA) with perinuclear staining (1:1280), myeloperoxidase (MPO) antibody level of 103 AU/mL (normal range, 0-19 AU/mL), serine proteinase 3 antibody level of 25 AU/mL (normal range, 0-19 AU/mL), and antihistone antibody level of 2.2 U (normal, <1.0 U). Negative levels of double-stranded DNA antibody and an antiphospholipid syndrome antibody panel were found. Results of a lung specimen biopsy showed reactive inflammation and were negative for malignant neoplasm.
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Corresponding Author: Michael A. Cardis, MD, Medstar Washington Hospital Center, Georgetown University Hospital, 5530 Wisconsin Ave, Ste 730, Chevy Chase, MD 20815 (email@example.com).
Published Online: August 26, 2020. doi:10.1001/jamadermatol.2020.2420
Conflict of Interest Disclosures: None reported.
Additional Contributions: We thank the patient for granting permission to publish this information.
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