How long is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA detected in children, and are children with coronavirus disease 2019 (COVID-19) identifiable by symptoms?
In this case series of 91 children with COVID-19 in Korea, 22.0% were asymptomatic. Only 8.5% of symptomatic cases were diagnosed at the time of symptom onset, while 66.2% had unrecognized symptoms before diagnosis and 25.4% developed symptoms after diagnosis; SARS-CoV-2 RNA was detected for a mean of 17.6 days overall and 14.1 days in asymptomatic cases.
Symptom screening fails to identify most COVID-19 cases in children, and SARS-CoV-2 RNA in children is detected for an unexpectedly long time.
There is limited information describing the full spectrum of coronavirus disease 2019 (COVID-19) and the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA detection in children.
To analyze the full clinical course and the duration of SARS-CoV-2 RNA detectability in children confirmed with COVID-19 in the Republic of Korea, where rigorous public health interventions have been implemented.
Design, Setting, and Participants
This case series of children with COVID-19 was conducted in 20 hospitals and 2 nonhospital isolation facilities across the country from February 18, 2020, to March 31, 2020. Children younger than 19 years who had COVID-19 were included.
Confirmed COVID-19, detected via SARS-CoV-2 RNA in a combined nasopharyngeal and oropharyngeal swab or sputum by real-time reverse transcription–polymerase chain reaction.
Main Outcomes and Measures
Clinical manifestations during the observation period, including the time and duration of symptom occurrence. The duration of SARS-CoV-2 RNA detection was also analyzed.
A total of 91 children with COVID-19 were included (median [range] age, 11 [0-18] years; 53 boys [58%]). Twenty children (22%) were asymptomatic during the entire observation period. Among 71 symptomatic cases, 47 children (66%) had unrecognized symptoms before diagnosis, 18 (25%) developed symptoms after diagnosis, and only 6 (9%) were diagnosed at the time of symptom onset. Twenty-two children (24%) had lower respiratory tract infections. The mean (SD) duration of the presence of SARS-CoV-2 RNA in upper respiratory samples was 17.6 (6.7) days. Virus RNA was detected for a mean (SD) of 14.1 (7.7) days in asymptomatic individuals. There was no difference in the duration of virus RNA detection between children with upper respiratory tract infections and lower respiratory tract infections (mean [SD], 18.7 [5.8] days vs 19.9 [5.6] days; P = .54). Fourteen children (15%) were treated with lopinavir-ritonavir and/or hydroxychloroquine. All recovered, without any fatal cases.
Conclusions and Relevance
In this case series study, inapparent infections in children may have been associated with silent COVID-19 transmission in the community. Heightened surveillance using laboratory screening will allow detection in children with unrecognized SARS-CoV-2 infection.
Sign in to take quiz and track your certificates
JN Learning™ is the home for CME and MOC from the JAMA Network. Search by specialty or US state and earn AMA PRA Category 1 Credit(s)™ from articles, audio, Clinical Challenges and more. Learn more about CME/MOC
CME Disclosure Statement: Unless noted, all individuals in control of content reported no relevant financial relationships. If applicable, all relevant financial relationships have been mitigated.
Accepted for Publication: June 17, 2020.
Corresponding Authors: Jong-Hyun Kim, MD, PhD, Department of Pediatrics, St Vincent's Hospital, The Catholic University of Korea, 93 Jungbu-daero, Paldal-gu, Suwon-si, Gyeonggi-do, Korea, 16247 (firstname.lastname@example.org); Eun Hwa Choi, MD, PhD, Department of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, Korea, 03080 (email@example.com).
Published Online: August 28, 2020. doi:10.1001/jamapediatrics.2020.3988
Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2020 Han MS et al. JAMA Pediatrics.
Author Contributions: Drs Han and Choi had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Concept and design: Han, E. Choi, Jong-Hyun Kim.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Han, E. Choi, S. Park, Choe.
Critical revision of the manuscript for important intellectual content: Han, E. Choi, Chang, Jin, E. Lee, B. Kim, M. Kim, Doo, Seo, Yae-Jean Kim, Yeo Jin Kim, J. Park, Suh, H. Lee, E. Cho, D. Kim, Jong Min Kim, H. Kim, J. Lee, D. Jo, S. Cho, J. Choi, K. Jo, Choe, K. Kim, Jong-Hyun Kim.
Statistical analysis: Han, Choe.
Administrative, technical, or material support: Han, E. Choi, Chang, Jin, E. Lee, B. Kim, M. Kim, Doo, Seo, Yae-Jean Kim, Yeo Jin Kim, J. Park, Suh, H. Lee, E. Cho, D. Kim, Jong Min Kim, H. Kim, S. Park, J. Lee, D. Jo, S. Cho, J. Choi, K. Jo, K. Kim, Jong-Hyun Kim.
Supervision: E. Choi, Jong-Hyun Kim.
Conflict of Interest Disclosures: None reported.
Additional Contributions: We thank all the medical staff at hospitals, city and provincial medical centers, and community facilities for their dedication to provide care for COVID-19; staff at the local health departments for their dedication; members of the Korean Society of Pediatric Infectious Diseases for their valuable advice on the management of COVID-19 cases; and staff at the Korea Centers for Disease Control and Prevention for their tireless efforts to combat this public health emergency.
Credit Designation Statement: The American Medical Association designates this Journal-based CME activity activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to:
It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting MOC credit.
You currently have no searches saved.
You currently have no courses saved.