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Corticosteroids, such as hydrocortisone and dexamethasone, have anti-inflammatory, antifibrotic, and vasoconstrictive effects, which intensivists have been trying to leverage for decades to improve outcomes in patients with acute respiratory distress syndrome (ARDS) and septic shock. In the first description of ARDS in 1967, Ashbaugh and colleagues noted that “corticosteroids appeared to have value in the treatment of patients with fat-embolism and possibly viral pneumonia.”1
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Corresponding Author: Todd W. Rice, MD, MSc, Department of Medicine, Vanderbilt University, T-1218 MCN, Nashville, TN 37232 (firstname.lastname@example.org).
Published Online: September 2, 2020. doi:10.1001/jama.2020.16747
Conflict of Interest Disclosures: Dr Prescott reported she serves on the Surviving Sepsis Campaign Guidelines Panel. Dr Rice reported personal fees from Cumberland Pharmaceuticals and personal fees from Avisa Pharmaceutical outside the submitted work.
Funding/Support: This content is the result of work supported with resources and use of facilities at the Ann Arbor VA Medical Center.
Role of the Funder/Sponsor: The Ann Arbor VA Medical Center had no role in the preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: This article does not represent the views of the Department of Veterans Affairs or the US government.
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